Elapor1 endosome-lysosome associated apoptosis and autophagy regulator 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Elapor1provided by MGI
Official Full Name: endosome-lysosome associated apoptosis and autophagy regulator 1provided by MGI
Primary source: MGI:MGI:1923930
See related: Ensembl:ENSMUSG00000040412 AllianceGenome:MGI:1923930
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Iir; Inceptor; 5330417C22Rik
Summary: Predicted to be involved in autophagosome assembly; cellular response to starvation; and positive regulation of autophagosome assembly. Predicted to be located in Golgi apparatus; bounding membrane of organelle; and endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Predicted to colocalize with late endosome; lysosome; and trans-Golgi network. Orthologous to human ELAPOR1 (endosome-lysosome associated apoptosis and autophagy regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 38.0), colon adult (RPKM 28.0) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F3; 3 47.14 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (108362995..108444064, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (108455679..108536745, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis.
Title: ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (5) 1 citation

General gene information

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Markers

D3Mit56 (e-PCR), detects polymorphism
- UniSTS:129824

UniSTS:234803 (e-PCR)
- UniSTS:234803

RH126688 (e-PCR)
- UniSTS:207553

BB183350 (e-PCR)
- UniSTS:185560

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vacuole organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vacuole organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with late endosome	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with lysosome	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with lysosome	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: endosome/lysosome-associated apoptosis and autophagy regulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033304.2 → NP_001028476.1 endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 2

See identical proteins and their annotated locations for NP_001028476.1

Status: VALIDATED

Source sequence(s)

AK139330, AL672200, AL683823, BP763374

Consensus CDS

CCDS17761.1

UniProtKB/Swiss-Prot

A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215

Related

ENSMUSP00000040128.7, ENSMUST00000048012.13

Conserved Domains (2) summary

pfam07562
Location:279 → 315

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl22855
Location:163 → 295

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
NM_001346518.1 → NP_001333447.1 endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL672200, AL683823, BP763374

Consensus CDS

CCDS84664.1

UniProtKB/Swiss-Prot

A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215

UniProtKB/TrEMBL

A0A0A0MQC6

Related

ENSMUSP00000102236.4, ENSMUST00000106625.10
NM_001358063.1 → NP_001344992.1 endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AL672200, AL683823, BP763374

UniProtKB/Swiss-Prot

A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215

Conserved Domains (1) summary

cl22855
Location:265 → 397

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
NM_001358064.1 → NP_001344993.1 endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AL672200, AL683823, BP763374

UniProtKB/Swiss-Prot

A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215

Conserved Domains (1) summary

cl22855
Location:265 → 397

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
NM_001358065.1 → NP_001344994.1 endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform 5

Status: VALIDATED

Source sequence(s)

AL672200, AL683823, BP763374

UniProtKB/Swiss-Prot

A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215

Conserved Domains (1) summary

cl22855
Location:163 → 295

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

108362995..108444064 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252595.2 → XP_030108455.1 endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform X2

UniProtKB/Swiss-Prot

A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215

Conserved Domains (3) summary

cd00185
Location:193 → 228

TNFRSF; CRD2 [structural motif]

pfam07562
Location:279 → 315

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl22855
Location:163 → 295

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_006501415.4 → XP_006501478.1 endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform X1

See identical proteins and their annotated locations for XP_006501478.1

UniProtKB/Swiss-Prot

A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215

Conserved Domains (2) summary

pfam07562
Location:279 → 315

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl22855
Location:163 → 295

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
XM_006501414.5 → XP_006501477.1 endosome/lysosome-associated apoptosis and autophagy regulator 1 isoform X1

See identical proteins and their annotated locations for XP_006501477.1

UniProtKB/Swiss-Prot

A2AFS2, A2AFS3, Q3UTM2, Q69ZL9, Q7TS96, Q8R215

Conserved Domains (2) summary

pfam07562
Location:279 → 315

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl22855
Location:163 → 295

TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)