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    Dzank1 double zinc ribbon and ankyrin repeat domains 1 [ Mus musculus (house mouse) ]

    Gene ID: 241688, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dzank1provided by MGI
    Official Full Name
    double zinc ribbon and ankyrin repeat domains 1provided by MGI
    Primary source
    MGI:MGI:2139080
    See related
    Ensembl:ENSMUSG00000037259 AllianceGenome:MGI:2139080
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ankrd64; 2810039F03Rik; 6330439K17Rik
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in eye photoreceptor cell development. Predicted to be located in centrosome. Is expressed in eye; nervous system; and reproductive system. Orthologous to human DZANK1 (double zinc ribbon and ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 22.9), frontal lobe adult (RPKM 19.6) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dzank1 in Genome Data Viewer
    Location:
    2 G1; 2 71.02 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (144312475..144369427, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (144470555..144527507, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 46768 Neighboring gene zinc finger protein 133, pseudogene Neighboring gene STARR-seq mESC enhancer starr_05917 Neighboring gene STARR-seq mESC enhancer starr_05918 Neighboring gene polymerase (RNA) III (DNA directed) polypeptide F Neighboring gene retinoblastoma binding protein 9, serine hydrolase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Association of a Chromosomal Rearrangement Event with Mouse Posterior Polymorphous Corneal Dystrophy and Alterations in Csrp2bp, Dzank1, and Ovol2 Gene Expression. Shen AL, et al. PLoS One, 2016. PMID 27310661, Free PMC Article
    2. Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome. Li J, et al. Sci Signal, 2016 Aug 9. PMID 27507650
    3. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087
    4. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article
    5. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association of a chromosomal rearrangement event with mouse posterior polymorphous corneal dystrophy and alterations in Csrp2bp, Dzank1, and Ovol2 gene expression have been reported.
      Title: Association of a Chromosomal Rearrangement Event with Mouse Posterior Polymorphous Corneal Dystrophy and Alterations in Csrp2bp, Dzank1, and Ovol2 Gene Expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107224, 6430408C01, 2810039F03Rik, 6330439K17Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in eye photoreceptor cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    double zinc ribbon and ankyrin repeat-containing protein 1
    Names
    ankyrin repeat-containing protein C20orf12 homolog
    likely ortholog of H. sapiens chromosome 20 open reading frame 12 (C20orf12)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360361.1 → NP_001347290.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL808119
      UniProtKB/TrEMBL
      B7ZNV9, E9Q4Z6
      Conserved Domains (5) summary
      cd00204
      Location:602 → 706
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00025
      Location:229 → 249
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00045
      Location:624 → 656
      ANK; ANK repeat [structural motif]
      pfam12773
      Location:311 → 365
      DZR; Double zinc ribbon
      pfam13287
      Location:32 → 100
      Fn3_assoc; Fn3 associated

    2. NM_001360362.1 → NP_001347291.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region, resulting in a frameshift and a novel 3' UTR, compared to variant 1. The encoded isoform (3) is shorter, and has a novel C-terminus, compared to isoform 1.
      Source sequence(s)
      AL808119
      UniProtKB/TrEMBL
      E9Q4Z6
      Conserved Domains (4) summary
      PRK14559
      Location:359 → 458
      PRK14559; putative protein serine/threonine phosphatase; Provisional
      sd00025
      Location:229 → 249
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam12773
      Location:359 → 407
      DZR; Double zinc ribbon
      pfam13287
      Location:32 → 100
      Fn3_assoc; Fn3 associated

    3. NM_001360363.1 → NP_001347292.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons, resulting in a frameshift and a novel 3' UTR, compared to variant 1. The encoded isoform (4) is shorter, and has a novel C-terminus, compared to isoform 1.
      Source sequence(s)
      AK163994, AL808119, BY254795, CJ256961
      Conserved Domains (3) summary
      sd00025
      Location:229 → 249
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam12773
      Location:311 → 365
      DZR; Double zinc ribbon
      pfam13287
      Location:32 → 100
      Fn3_assoc; Fn3 associated

    4. NM_172859.3 → NP_766447.2  double zinc ribbon and ankyrin repeat-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_766447.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK032182, AK032632, AK163994, AL808119, BY254795, CJ256961
      Consensus CDS
      CCDS38254.1
      UniProtKB/Swiss-Prot
      A2AN93, Q8C008, Q8C060
      UniProtKB/TrEMBL
      E9Q4Z6
      Related
      ENSMUSP00000080643.6, ENSMUST00000081982.12
      Conserved Domains (6) summary
      cd00204
      Location:644 → 748
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00025
      Location:229 → 249
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam03174
      Location:12 → 97
      CHB_HEX_C; Chitobiase/beta-hexosaminidase C-terminal domain
      pfam12773
      Location:359 → 407
      DZR; Double zinc ribbon
      pfam12796
      Location:644 → 730
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:666 → 698
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      144312475..144369427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239534.3 → XP_011237836.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      E9Q4Z6
      Conserved Domains (5) summary
      sd00025
      Location:229 → 249
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00045
      Location:638 → 670
      ANK; ANK repeat [structural motif]
      pfam12773
      Location:311 → 365
      DZR; Double zinc ribbon
      pfam13287
      Location:32 → 100
      Fn3_assoc; Fn3 associated
      cl39094
      Location:626 → 705
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_006499512.4 → XP_006499575.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      E9Q4Z6
      Conserved Domains (6) summary
      PRK14559
      Location:358 → 457
      PRK14559; serine/threonine phosphatase
      sd00025
      Location:272 → 289
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00045
      Location:665 → 697
      ANK; ANK repeat [structural motif]
      pfam12773
      Location:358 → 406
      DZR; Double zinc ribbon
      pfam12796
      Location:643 → 732
      Ank_2; Ankyrin repeats (3 copies)
      pfam13287
      Location:32 → 100
      Fn3_assoc; Fn3 associated

    3. XM_011239532.3 → XP_011237834.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      E9Q4Z6
      Conserved Domains (6) summary
      PRK14559
      Location:358 → 457
      PRK14559; serine/threonine phosphatase
      sd00025
      Location:272 → 289
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00045
      Location:679 → 711
      ANK; ANK repeat [structural motif]
      pfam12773
      Location:358 → 406
      DZR; Double zinc ribbon
      pfam13287
      Location:32 → 100
      Fn3_assoc; Fn3 associated
      cl39094
      Location:667 → 746
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_006499511.4 → XP_006499574.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006499574.1

      UniProtKB/TrEMBL
      B2RUH8, E9Q4Z6
      Conserved Domains (6) summary
      PRK14559
      Location:359 → 458
      PRK14559; serine/threonine phosphatase
      sd00025
      Location:229 → 249
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00045
      Location:680 → 712
      ANK; ANK repeat [structural motif]
      pfam12773
      Location:359 → 407
      DZR; Double zinc ribbon
      pfam13287
      Location:32 → 100
      Fn3_assoc; Fn3 associated
      cl39094
      Location:668 → 747
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_030251166.2 → XP_030107026.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      E9Q4Z6
      Conserved Domains (6) summary
      sd00025
      Location:230 → 249
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00045
      Location:586 → 618
      ANK; ANK repeat [structural motif]
      pfam12773
      Location:273 → 327
      DZR; Double zinc ribbon
      pfam12796
      Location:564 → 653
      Ank_2; Ankyrin repeats (3 copies)
      pfam13287
      Location:32 → 100
      Fn3_assoc; Fn3 associated
      pfam14803
      Location:245 → 278
      Nudix_N_2; Nudix N-terminal

    6. XM_036161991.1 → XP_036017884.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      E9Q4Z6
      Conserved Domains (6) summary
      PRK14559
      Location:321 → 420
      PRK14559; serine/threonine phosphatase
      sd00025
      Location:229 → 249
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00045
      Location:628 → 660
      ANK; ANK repeat [structural motif]
      pfam12773
      Location:321 → 369
      DZR; Double zinc ribbon
      pfam12796
      Location:606 → 695
      Ank_2; Ankyrin repeats (3 copies)
      pfam13287
      Location:32 → 100
      Fn3_assoc; Fn3 associated

    7. XM_011239533.4 → XP_011237835.1  double zinc ribbon and ankyrin repeat-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      E9Q4Z6
      Conserved Domains (6) summary
      PRK14559
      Location:321 → 420
      PRK14559; serine/threonine phosphatase
      sd00025
      Location:229 → 249
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      sd00045
      Location:642 → 674
      ANK; ANK repeat [structural motif]
      pfam12773
      Location:321 → 369
      DZR; Double zinc ribbon
      pfam13287
      Location:32 → 100
      Fn3_assoc; Fn3 associated
      cl39094
      Location:630 → 709
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C008.2 GenPept UniProtKB/Swiss-Prot:Q8C008

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