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    Exosc2 exosome component 2 [ Mus musculus (house mouse) ]

    Gene ID: 227715, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Exosc2provided by MGI
    Official Full Name
    exosome component 2provided by MGI
    Primary source
    MGI:MGI:2385133
    See related
    Ensembl:ENSMUSG00000039356 AllianceGenome:MGI:2385133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rrp4
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in RNA metabolic process and positive regulation of cell growth. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Is expressed in several structures, including cerebral cortex; gonad; liver; metanephros; and muscle tissue. Human ortholog(s) of this gene implicated in short stature, hearing loss, retinitis pigmentosa, and distinctive facies. Orthologous to human EXOSC2 (exosome component 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 19.1), liver E14 (RPKM 15.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Exosc2 in Genome Data Viewer
    Location:
    2 B; 2 21.86 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (31560727..31571593)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (31670715..31681352)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene far upstream element (FUSE) binding protein 3 Neighboring gene microRNA 6998 Neighboring gene PR domain containing 12 Neighboring gene STARR-positive B cell enhancer ABC_E1585 Neighboring gene STARR-positive B cell enhancers ABC_E2611 and ABC_E9068 Neighboring gene predicted gene 13427 Neighboring gene predicted gene, 57832 Neighboring gene c-abl oncogene 1, non-receptor tyrosine kinase Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:31615309-31615418 Neighboring gene pyroglutamylated RFamide peptide

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exosome complex components 1 and 2 are vital for early mammalian development. Srinivasan S, et al. Gene Expr Patterns, 2024 Mar. PMID 37940010,
    2. Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling. Ulmke PA, et al. Development, 2021 Feb 8. PMID 33462115, Free PMC Article
    3. The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L. Tomecki R, et al. EMBO J, 2010 Jul 21. PMID 20531386, Free PMC Article
    4. The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters. Aleidi SM, et al. J Biol Chem, 2015 Oct 2. PMID 26296893, Free PMC Article
    5. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30456

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CUT catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in TRAMP-dependent tRNA surveillance pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly(A)-dependent snoRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of nucleolar exosome (RNase complex) NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    exosome complex component RRP4
    Names
    exosome complex exonuclease RRP4
    homolog of Yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144886.3 → NP_659135.1  exosome complex component RRP4

      See identical proteins and their annotated locations for NP_659135.1

      Status: VALIDATED

      Source sequence(s)
      AK166881, AL929275
      Consensus CDS
      CCDS15900.1
      UniProtKB/Swiss-Prot
      Q8VBV3
      UniProtKB/TrEMBL
      A2AV19, Q3TKQ3
      Related
      ENSMUSP00000043519.8, ENSMUST00000038474.14
      Conserved Domains (1) summary
      COG1097
      Location:22 → 205
      Rrp4; Exosome complex RNA-binding protein Rrp4, contains S1 and KH domains [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      31560727..31571593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497944.4 → XP_006498007.1  exosome complex component RRP4 isoform X1

      Conserved Domains (1) summary
      COG1097
      Location:8 → 93
      Rrp4; Exosome complex RNA-binding protein Rrp4, contains S1 and KH domains [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VBV3.1 GenPept UniProtKB/Swiss-Prot:Q8VBV3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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