Parvb parvin, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Parvbprovided by MGI
Official Full Name: parvin, betaprovided by MGI
Primary source: MGI:MGI:2153063
See related: Ensembl:ENSMUSG00000022438 AllianceGenome:MGI:2153063
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D15Gsk1; affixin
Summary: Predicted to enable actin binding activity. Predicted to be involved in several processes, including establishment or maintenance of cell polarity regulating cell shape; lamellipodium assembly; and substrate adhesion-dependent cell spreading. Predicted to be located in cytosol. Predicted to be active in several cellular components, including actin cytoskeleton; focal adhesion; and lamellipodium. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; liver; and sensory organ. Orthologous to human PARVB (parvin beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 18.6), lung adult (RPKM 17.3) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E2; 15 39.78 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (84116244..84199890)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (84232043..84315689)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Parvins are critical for the organization of endothelial cell-cell junctions, the establishment of endothelial apical-basal polarity, and the integrity of the basement membrane.
Title: Parvins Are Required for Endothelial Cell-Cell Junctions and Cell Polarity During Embryonic Blood Vessel Formation.
Data from functional molecular imaging demonstrated that beta-parvin plays a regulatory role in the ILK-mediated Akt (also called protein kinase B) signaling cascades, suggesting that beta-parvin might be a crucial modulator of cell survival.
Title: Functional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of beta-parvin.
Data show that affixin is a dysferlin binding protein that colocalizes with dysferlin at the sarcolemma of normal skeletal muscle.
Title: Dysferlin interacts with affixin (beta-parvin) at the sarcolemma.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237367

AI595373 (e-PCR)
- UniSTS:165953

AW742462 (e-PCR)
- UniSTS:209124

RH126868 (e-PCR)
- UniSTS:209125

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell projection assembly	ISO Inferred from Sequence Orthology more info
involved_in cell projection assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment or maintenance of cell polarity regulating cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of cell polarity regulating cell shape	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of cell polarity regulating cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in substrate adhesion-dependent cell spreading	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-parvin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133167.3 → NP_573395.1 beta-parvin

See identical proteins and their annotated locations for NP_573395.1

Status: VALIDATED

Source sequence(s)

AK147758, AL626769

Consensus CDS

CCDS37167.1

UniProtKB/Swiss-Prot

Q9ES46

UniProtKB/TrEMBL

Q3UGT9

Related

ENSMUSP00000023072.7, ENSMUST00000023072.7

Conserved Domains (1) summary

pfam00307
Location:89 → 190

CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

84116244..84199890

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520532.4 → XP_006520595.2 beta-parvin isoform X1

Conserved Domains (1) summary

pfam00307
Location:51 → 158

CH; Calponin homology (CH) domain
XM_030248364.1 → XP_030104224.1 beta-parvin isoform X2

Conserved Domains (1) summary

pfam00307
Location:36 → 143

CH; Calponin homology (CH) domain