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    Pfn4 profilin family, member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 494222, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pfn4provided by RGD
    Official Full Name
    profilin family, member 4provided by RGD
    Primary source
    RGD:1359707
    See related
    EnsemblRapid:ENSRNOG00000050386 AllianceGenome:RGD:1359707
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin monomer binding activity. Predicted to be involved in sequestering of actin monomers and spermatid development. Predicted to be active in cell cortex. Orthologous to human PFN4 (profilin family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 71.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pfn4 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (33506077..33516163)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (27786619..27796710)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (30027915..30038000, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 228, member A Neighboring gene uncharacterized LOC134479113 Neighboring gene family with sequence similarity 228, member B Neighboring gene tumor protein p53 inducible protein 3 Neighboring gene splicing factor 3B, subunit 6 Neighboring gene FKBP prolyl isomerase 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel testis-expressed profilin IV associated with acrosome biogenesis and spermatid elongation. Obermann H, et al. Mol Hum Reprod, 2005 Jan. PMID 15591451
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin monomer binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in acrosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in manchette assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in manchette assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sequestering of actin monomers IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm flagellum assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm flagellum assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    profilin-4
    Names
    profilin IV

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009503.2 → NP_001009503.1  profilin-4

      See identical proteins and their annotated locations for NP_001009503.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q5IRJ7
      UniProtKB/TrEMBL
      A6HAJ2
      Related
      ENSRNOP00000064666.1, ENSRNOT00000074570.3
      Conserved Domains (1) summary
      pfam00235
      Location:14 → 126
      Profilin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      33506077..33516163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112671.1 → XP_038968599.1  profilin-4 isoform X1

      UniProtKB/Swiss-Prot
      Q5IRJ7
      UniProtKB/TrEMBL
      A6HAJ2
      Conserved Domains (1) summary
      pfam00235
      Location:14 → 126
      Profilin

    2. XM_039112672.1 → XP_038968600.1  profilin-4 isoform X1

      UniProtKB/Swiss-Prot
      Q5IRJ7
      UniProtKB/TrEMBL
      A6HAJ2
      Conserved Domains (1) summary
      pfam00235
      Location:14 → 126
      Profilin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5IRJ7.1 GenPept UniProtKB/Swiss-Prot:Q5IRJ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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