Pla2g12b phospholipase A2, group XIIB [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pla2g12bprovided by RGD
Official Full Name: phospholipase A2, group XIIBprovided by RGD
Primary source: RGD:1588484
See related: EnsemblRapid:ENSRNOG00000046619 AllianceGenome:RGD:1588484
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable calcium ion binding activity and phospholipase A2 activity. Predicted to be involved in cholesterol homeostasis and triglyceride homeostasis. Predicted to act upstream of or within low-density lipoprotein particle remodeling. Predicted to be located in extracellular region. Orthologous to human PLA2G12B (phospholipase A2 group XIIB). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Restricted expression toward (RPKM 239.7) See more
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (27910620..27931734)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (27369196..27389517)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (28989440..29007967)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase A2 activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arachidonate secretion	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within triglyceride homeostasis	ISO Inferred from Sequence Orthology more info