Cd226 CD226 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd226provided by RGD
Official Full Name: CD226 moleculeprovided by RGD
Primary source: RGD:1311513
See related: EnsemblRapid:ENSRNOG00000038197 AllianceGenome:RGD:1311513
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity; integrin binding activity; and protein kinase binding activity. Predicted to be involved in positive regulation of immune response and positive regulation of mast cell activation. Predicted to act upstream of or within positive regulation of natural killer cell cytokine production and positive regulation of type II interferon production. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane. Orthologous to human CD226 (CD226 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 94.0), Thymus (RPKM 74.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (84723330..84819836)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (82449924..82545107)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (86299392..86394772)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

his study showed that CD226 Gly307Ser may correlate with risk of neuromyelitis optica in Southern Han Chinese.
Title: CD226 Gly307Ser association with neuromyelitis optica in Southern Han Chinese.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of natural killer cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CD226 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107370.1 → NP_001100840.1 CD226 antigen precursor

See identical proteins and their annotated locations for NP_001100840.1

Status: PROVISIONAL

Source sequence(s)

CH474021

UniProtKB/TrEMBL

A6K5P0, D3ZS97

Related

ENSRNOP00000054956.2, ENSRNOT00000058152.5

Conserved Domains (3) summary

cd05889
Location:44 → 141

Ig1_DNAM-1_like; First immunoglobulin (Ig) domain of DNAX accessory molecule 1 (DNAM-1, also known as CD226) and similar proteins

smart00410
Location:152 → 255

IG_like; Immunoglobulin like

cl11960
Location:151 → 239

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

84723330..84819836

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096759.2 → XP_038952687.1 CD226 antigen isoform X1

UniProtKB/TrEMBL

A6K5P1

Related

ENSRNOP00000111825.1, ENSRNOT00000172632.1

Conserved Domains (1) summary

cd05889
Location:17 → 128

IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains
XM_006255028.5 → XP_006255090.1 CD226 antigen isoform X1

See identical proteins and their annotated locations for XP_006255090.1

UniProtKB/TrEMBL

A6K5P1

Conserved Domains (1) summary

cd05889
Location:17 → 128

IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains
XM_006255031.5 → XP_006255093.1 CD226 antigen isoform X1

See identical proteins and their annotated locations for XP_006255093.1

UniProtKB/TrEMBL

A6K5P1

Conserved Domains (1) summary

cd05889
Location:17 → 128

IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains
XM_039096758.2 → XP_038952686.1 CD226 antigen isoform X1

UniProtKB/TrEMBL

A6K5P1

Conserved Domains (1) summary

cd05889
Location:17 → 128

IgV_1_DNAM-1_like; First immunoglobulin variable (IgV) domain of DNAX accessory molecule 1, and similar domains
XM_063277286.1 → XP_063133356.1 CD226 antigen isoform X1

UniProtKB/TrEMBL

A6K5P1