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    Psmc6 proteasome 26S subunit, ATPase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289990, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Psmc6provided by RGD
    Official Full Name
    proteasome 26S subunit, ATPase 6provided by RGD
    Primary source
    RGD:1308825
    See related
    EnsemblRapid:ENSRNOG00000007203 AllianceGenome:RGD:1308825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and proteasome-activating activity. Involved in positive regulation of inclusion body assembly. Located in inclusion body. Part of cytosolic proteasome complex. Orthologous to human PSMC6 (proteasome 26S subunit, ATPase 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 356.7), Liver (RPKM 356.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Psmc6 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (21022314..21043785)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (18542585..18564057)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (19667453..19688916)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S10 like 6 Neighboring gene G protein-coupled receptor 137C Neighboring gene REST corepressor 2, pseudogene 1 Neighboring gene endoplasmic reticulum oxidoreductase 1 alpha Neighboring gene farnesyl diphosphate synthase pseudogene Neighboring gene serine/threonine/tyrosine interacting protein Neighboring gene glucosamine-phosphate N-acetyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones. Rousseau E, et al. J Biol Chem, 2009 Jan 16. PMID 18986984, Free PMC Article
    2. The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis. Yi H, et al. J Biol Chem, 2007 Nov 30. PMID 17911097
    3. Subcellular localization, stoichiometry, and protein levels of 26 S proteasome subunits in yeast. Russell SJ, et al. J Biol Chem, 1999 Jul 30. PMID 10419517
    4. Purification and characterization of 26S proteasomes from human and mouse spermatozoa. Tipler CP, et al. Mol Hum Reprod, 1997 Dec. PMID 9464850
    5. Mapping the murine cardiac 26S proteasome complexes. Gomes AV, et al. Circ Res, 2006 Aug 18. PMID 16857966

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of inclusion body assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in inclusion body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome accessory complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    26S proteasome regulatory subunit 10B
    Names
    26S protease regulatory subunit 10B
    proteasome (prosome, macropain) 26S subunit, ATPase, 6
    proteasome (prosome, macropain) 26S subunit, ATPase, 6-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100509.3 → NP_001093979.1  26S proteasome regulatory subunit 10B

      See identical proteins and their annotated locations for NP_001093979.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6KDZ6, G3V6W6, Q32PW9
      Related
      ENSRNOP00000009649.4, ENSRNOT00000009649.7
      Conserved Domains (1) summary
      COG1222
      Location:18 → 401
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      21022314..21043785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093096.2 → XP_038949024.1  26S proteasome regulatory subunit 10B isoform X1

      Conserved Domains (1) summary
      COG1222
      Location:1 → 286
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version

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