Cct4 chaperonin containing TCP1 subunit 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cct4provided by RGD
Official Full Name: chaperonin containing TCP1 subunit 4provided by RGD
Primary source: RGD:727937
See related: EnsemblRapid:ENSRNOG00000009642 AllianceGenome:RGD:727937
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein folding chaperone and unfolded protein binding activity. Predicted to be involved in several processes, including chaperone mediated protein folding independent of cofactor; positive regulation of protein localization to Cajal body; and positive regulation of telomerase RNA localization to Cajal body. Predicted to act upstream of with a positive effect on scaRNA localization to Cajal body. Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be located in several cellular components, including cell body; microtubule cytoskeleton; and nucleoplasm. Predicted to be part of chaperonin-containing T-complex and zona pellucida receptor complex. Used to study hereditary sensory neuropathy. Orthologous to human CCT4 (chaperonin containing TCP1 subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 1051.8), Thymus (RPKM 885.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (101193057..101205935)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (96991853..97004732)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (107767392..107780270)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C450Y CCT4 is defective in protein stability.
Title: Biochemical characterization of mutants in chaperonin proteins CCT4 and CCT5 associated with hereditary sensory neuropathy.
the mutation in Cct4 underlies cutaneous nerve degeneration in mutilated-foot rats.
Title: Cutaneous and sympathetic denervation in neonatal rats with a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 gene.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in chaperone mediated protein folding independent of cofactor	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to Cajal body	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of telomerase RNA localization to Cajal body	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect scaRNA localization to Cajal body	ISO Inferred from Sequence Orthology more info
involved_in sexual reproduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
part_of chaperonin-containing T-complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chaperonin-containing T-complex	ISO Inferred from Sequence Orthology more info
part_of chaperonin-containing T-complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of zona pellucida receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: T-complex protein 1 subunit delta

Names: CCT-delta; TCP-1-delta; chaperonin containing Tcp1, subunit 4 (delta); chaperonin subunit 4 (delta)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182814.2 → NP_877966.1 T-complex protein 1 subunit delta

See identical proteins and their annotated locations for NP_877966.1

Status: VALIDATED

Source sequence(s)

AY223861, BQ200856, CA340557, CB612673

UniProtKB/Swiss-Prot

Q7TPB1

UniProtKB/TrEMBL

A0A8I5YC75, A6JQ63

Related

ENSRNOP00000012847.3, ENSRNOT00000012847.5

Conserved Domains (2) summary

cd03338
Location:25 → 538

TCP1_delta; TCP-1 (CTT or eukaryotic type II) chaperonin family, delta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins ...

pfam00118
Location:44 → 539

Cpn60_TCP1; TCP-1/cpn60 chaperonin family