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    Ift81 intraflagellar transport 81 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 373066, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ift81provided by RGD
    Official Full Name
    intraflagellar transport 81provided by RGD
    Primary source
    RGD:727862
    See related
    EnsemblRapid:ENSRNOG00000001294 AllianceGenome:RGD:727862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cdv1; Cdv-1
    Summary
    Predicted to enable tubulin binding activity. Predicted to be involved in intraciliary transport involved in cilium assembly; regulation of smoothened signaling pathway; and sperm flagellum assembly. Predicted to be located in cytoplasm; microtubule organizing center; and sperm flagellum. Predicted to be part of intraciliary transport particle B. Predicted to be active in ciliary basal body. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 19 with or without polydactyly. Orthologous to human IFT81 (intraflagellar transport 81). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 128.4), Heart (RPKM 122.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ift81 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (39618559..39697971)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (33957744..34037164)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (39420161..39507412)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32, pseudogene 11 Neighboring gene purinergic receptor P2X 7 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Neighboring gene anaphase promoting complex subunit 7 Neighboring gene ribosomal protein L38, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Destabilization of the IFT-B cilia core complex due to mutations in IFT81 causes a Spectrum of Short-Rib Polydactyly Syndrome. Duran I, et al. Sci Rep, 2016 Sep 26. PMID 27666822, Free PMC Article
    2. Molecular basis of tubulin transport within the cilium by IFT74 and IFT81. Bhogaraju S, et al. Science, 2013 Aug 30. PMID 23990561, Free PMC Article
    3. Identification of human CDV-1R and mouse Cdv-1R, two novel proteins with putative signal peptides, especially highly expressed in testis and increased with the male sex maturation. Peng J, et al. Mol Biol Rep, 2002 Dec. PMID 12549821
    4. Genomic organization and mapping of mouse CDV (carnitine deficiency-associated gene expressed in ventricle)-1 and its related CDV-1R gene. Higashi M, et al. Mamm Genome, 2000 Dec. PMID 11130971
    5. Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17. Howard PW, et al. Exp Cell Res, 2013 Aug 15. PMID 23810713, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intraciliary transport involved in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intraciliary transport involved in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of smoothened signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sperm flagellum assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm flagellum assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm flagellum assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of intraciliary transport particle B ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of intraciliary transport particle B ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sperm midpiece IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm principal piece IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    intraflagellar transport protein 81 homolog
    Names
    carnitine deficiency-associated gene expressed in ventricle 1
    carnitine deficiency-associated protein expressed in ventricle 1
    intraflagellar transport 81 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199120.2 → NP_954551.2  intraflagellar transport protein 81 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      P83829
      UniProtKB/TrEMBL
      A0A8I6A5Q9, A6J187
      Conserved Domains (3) summary
      COG1196
      Location:340 → 621
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:141 → 406
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam18383
      Location:3 → 126
      IFT81_CH; Intraflagellar transport 81 calponin homology domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      39618559..39697971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089655.1 → XP_038945583.1  intraflagellar transport protein 81 homolog isoform X2

      UniProtKB/Swiss-Prot
      P83829
      UniProtKB/TrEMBL
      D4A562
      Conserved Domains (3) summary
      COG1196
      Location:340 → 621
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:141 → 406
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam18383
      Location:3 → 126
      IFT81_CH; Intraflagellar transport 81 calponin homology domain

    2. XM_039089656.2 → XP_038945584.1  intraflagellar transport protein 81 homolog isoform X3

      UniProtKB/Swiss-Prot
      P83829
      Conserved Domains (3) summary
      COG1196
      Location:340 → 621
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:141 → 406
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam18383
      Location:3 → 126
      IFT81_CH; Intraflagellar transport 81 calponin homology domain

    3. XM_039089654.2 → XP_038945582.1  intraflagellar transport protein 81 homolog isoform X1

      UniProtKB/Swiss-Prot
      P83829
      UniProtKB/TrEMBL
      A0A8I6A5Q9, A6J187
      Related
      ENSRNOP00000088207.1, ENSRNOT00000110153.2
      Conserved Domains (3) summary
      COG1196
      Location:340 → 621
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:141 → 406
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam18383
      Location:3 → 126
      IFT81_CH; Intraflagellar transport 81 calponin homology domain

    4. XM_063271568.1 → XP_063127638.1  intraflagellar transport protein 81 homolog isoform X2

      UniProtKB/TrEMBL
      D4A562
      Related
      ENSRNOP00000061697.3, ENSRNOT00000066952.4

    5. XM_063271569.1 → XP_063127639.1  intraflagellar transport protein 81 homolog isoform X3

      Related
      ENSRNOP00000091754.2, ENSRNOT00000119159.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83829.1 GenPept UniProtKB/Swiss-Prot:P83829

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