Nemf nuclear export mediator factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nemfprovided by RGD
Official Full Name: nuclear export mediator factorprovided by RGD
Primary source: RGD:2315525
See related: EnsemblRapid:ENSRNOG00000056128 AllianceGenome:RGD:2315525
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sdccag1
Summary: Predicted to enable alpha-aminoacyl-tRNA binding activity and ribosomal large subunit binding activity. Predicted to be involved in CAT tailing; nuclear export; and protein-containing complex assembly. Predicted to be located in cytosol. Predicted to be part of RQC complex. Predicted to be active in cytosolic ribosome. Orthologous to human NEMF (nuclear export mediator factor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 149.6), Kidney (RPKM 148.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (93527690..93571863, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (87791650..87835826, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (91611021..91676394, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH144072 (e-PCR)
- UniSTS:233318

AU022198 (e-PCR)
- UniSTS:167091

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-aminoacyl-tRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosomal large subunit binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CAT tailing	ISO Inferred from Sequence Orthology more info
involved_in nuclear export	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in ribosome-associated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RQC complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribosome quality control complex subunit NEMF

Names: nuclear export mediator factor NEMF; serologically defined colon cancer antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170586.3 → NP_001164057.2 ribosome quality control complex subunit NEMF

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A8I6A2E1, A0A8I6ARH7

Related

ENSRNOP00000084632.1, ENSRNOT00000098306.2

Conserved Domains (2) summary

COG1293
Location:1 → 642

YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]

pfam11923
Location:964 → 1055

DUF3441; Domain of unknown function (DUF3441)