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    Ifi211 interferon activated gene 211 [ Mus musculus (house mouse) ]

    Gene ID: 381308, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ifi211provided by MGI
    Official Full Name
    interferon activated gene 211provided by MGI
    Primary source
    MGI:MGI:3041120
    See related
    Ensembl:ENSMUSG00000026536 AllianceGenome:MGI:3041120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mnda; Ifi205b; ifi-205-B; A730048F03
    Summary
    The protein encoded by this gene is a member of the interferon-regulated 200 family of proteins, which contain an N-terminal pyrin domain that is proposed to function in cell death and a partially conserved 220 amino acid domain. Expression of this protein in embryonic stem cells is critical for the DNA damage response and regulation of cell survival. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
    Expression
    Broad expression in liver E18 (RPKM 4.0), bladder adult (RPKM 2.7) and 15 other tissues See more
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    Genomic context

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    See Ifi211 in Genome Data Viewer
    Location:
    1 H3; 1 80.74 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173723907..173740650, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173896339..173913087, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03084 Neighboring gene myeloid nuclear differentiation antigen like Neighboring gene STARR-positive B cell enhancer ABC_E801 Neighboring gene predicted gene, 21031 Neighboring gene STARR-positive B cell enhancer ABC_E11108 Neighboring gene interferon activated gene 203 Neighboring gene STARR-positive B cell enhancer ABC_E3335 Neighboring gene STARR-positive B cell enhancer ABC_E11109 Neighboring gene interferon activated gene 202B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interferons as gene activators. Cloning of the 5' terminus and the control segment of an interferon activated gene. Samanta H, et al. J Biol Chem, 1986 Sep 5. PMID 3017948
    2. Apoptosis-related gene expression profiles of mouse ESCs and maGSCs: role of Fgf4 and Mnda in pluripotent cell responses to genotoxicity. Khromov T, et al. PLoS One, 2012. PMID 23145002, Free PMC Article
    3. A lipopolysaccharide-inducible macrophage gene (D3) is a new member of an interferon-inducible gene cluster and is selectively expressed in mononuclear phagocytes. Tannenbaum CS, et al. J Leukoc Biol, 1993 May. PMID 7684766
    4. The mammalian PYHIN gene family: phylogeny, evolution and expression. Cridland JA, et al. BMC Evol Biol, 2012 Aug 7. PMID 22871040, Free PMC Article
    5. Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. Brunette RL, et al. J Exp Med, 2012 Oct 22. PMID 23045604, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of Mnda in response to apoptosis and genotoxic stress is discussed.
      Title: Apoptosis-related gene expression profiles of mouse ESCs and maGSCs: role of Fgf4 and Mnda in pluripotent cell responses to genotoxicity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in activation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to interferon-beta IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear periphery ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interferon-activable protein 211; interferon-activable protein 205-B
    Names
    interferon-inducible protein p205-B
    lipopolysaccharide-inducible
    myeloid cell nuclear differentiation antigen
    protein D3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033450.4 → NP_001028622.1  interferon-activable protein 211 isoform 1

      See identical proteins and their annotated locations for NP_001028622.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC170584, AK152683, AK166217, AV250999, CJ067068
      Consensus CDS
      CCDS15532.1
      UniProtKB/Swiss-Prot
      P0DOV1
      UniProtKB/TrEMBL
      A0A1Z3MI21
      Related
      ENSMUSP00000009340.9, ENSMUST00000009340.10
      Conserved Domains (2) summary
      cd08305
      Location:10 → 83
      Pyrin; Pyrin: a protein-protein interaction domain
      pfam02760
      Location:225 → 393
      HIN; HIN-200/IF120x domain

    2. NM_001301745.1 → NP_001288674.1  interferon-activable protein 211 isoform 2

      See identical proteins and their annotated locations for NP_001288674.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC170584, AK080485, AK152683, AK166217, AV250999, CJ067068
      UniProtKB/TrEMBL
      A0A1Z3MI21
      Conserved Domains (2) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
      pfam02760
      Location:223 → 391
      HIN; HIN-200/IF120x domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      173723907..173740650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036166133.1 → XP_036022026.1  interferon-activable protein 205-B isoform X1

      Conserved Domains (1) summary
      cd08305
      Location:10 → 83
      Pyrin; a protein-protein interaction domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DOV1.1 GenPept UniProtKB/Swiss-Prot:P0DOV1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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