Apoa4 apolipoprotein A-IV [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apoa4provided by MGI
Official Full Name: apolipoprotein A-IVprovided by MGI
Primary source: MGI:MGI:88051
See related: Ensembl:ENSMUSG00000032080 AllianceGenome:MGI:88051
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Apoa-4; apo-AIV; apoA-IV
Summary: Predicted to enable several functions, including cation binding activity; cholesterol transfer activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Involved in innate immune response in mucosa and response to stilbenoid. Acts upstream of or within regulation of intestinal cholesterol absorption. Located in extracellular space. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease; colitis; myocardial infarction; and ulcerative colitis. Orthologous to human APOA4 (apolipoprotein A4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in duodenum adult (RPKM 2830.4), small intestine adult (RPKM 1726.5) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 25.36 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (46152142..46154756)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (46240844..46243458)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Apolipoprotein A-IV-Deficient Mice in 129/SvJ Background Are Susceptible to Obesity and Glucose Intolerance.
Title: Apolipoprotein A-IV-Deficient Mice in 129/SvJ Background Are Susceptible to Obesity and Glucose Intolerance.
Apolipoprotein A4 Restricts Diet-Induced Hepatic Steatosis via SREBF1-Mediated Lipogenesis and Enhances IRS-PI3K-Akt Signaling.
Title: Apolipoprotein A4 Restricts Diet-Induced Hepatic Steatosis via SREBF1-Mediated Lipogenesis and Enhances IRS-PI3K-Akt Signaling.
Bmal1 regulates production of larger lipoproteins by modulating cAMP-responsive element-binding protein H and apolipoprotein AIV.
Title: Bmal1 regulates production of larger lipoproteins by modulating cAMP-responsive element-binding protein H and apolipoprotein AIV.
Disrupting the DREAM transcriptional repressor complex induces apolipoprotein overexpression and systemic amyloidosis in mice.
Title: Disrupting the DREAM transcriptional repressor complex induces apolipoprotein overexpression and systemic amyloidosis in mice.
Advanced Glycated apoA-IV Loses Its Ability to Prevent the LPS-Induced Reduction in Cholesterol Efflux-Related Gene Expression in Macrophages.
Title: Advanced Glycated apoA-IV Loses Its Ability to Prevent the LPS-Induced Reduction in Cholesterol Efflux-Related Gene Expression in Macrophages.
Apolipoprotein A4 regulates the immune response in carbon tetrachloride-induced chronic liver injury in mice.
Title: Apolipoprotein A4 regulates the immune response in carbon tetrachloride-induced chronic liver injury in mice.
Identification and characterization of proteins that are differentially expressed in adipose tissue of olanzapine-induced insulin resistance rat by iTRAQ quantitative proteomics.
Title: Identification and characterization of proteins that are differentially expressed in adipose tissue of olanzapine-induced insulin resistance rat by iTRAQ quantitative proteomics.
Central Apolipoprotein A-IV Stimulates Thermogenesis in Brown Adipose Tissue.
Title: Central Apolipoprotein A-IV Stimulates Thermogenesis in Brown Adipose Tissue.
Apolipoprotein A-IV acts as an endogenous anti-inflammatory protein and is reduced in treatment-naive allergic patients and allergen-challenged mice.
Title: Apolipoprotein A-IV acts as an endogenous anti-inflammatory protein and is reduced in treatment-naïve allergic patients and allergen-challenged mice.
ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice
Title: Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables antioxidant activity	ISO Inferred from Sequence Orthology more info
enables cholesterol transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables cholesterol transfer activity	IEA Inferred from Electronic Annotation more info
enables cholesterol transfer activity	ISO Inferred from Sequence Orthology more info
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine-sterol O-acyltransferase activator activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine-sterol O-acyltransferase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acylglycerol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	IEA Inferred from Electronic Annotation more info
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in innate immune response in mucosa	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response in mucosa	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lipid transport	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of plasma lipoprotein oxidation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of plasma lipoprotein oxidation	ISO Inferred from Sequence Orthology more info
involved_in peripheral nervous system axon regeneration	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid efflux	IEA Inferred from Electronic Annotation more info
involved_in phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of CoA-transferase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipoprotein lipase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein-lipid complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-lipid complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cholesterol transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cholesterol transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of intestinal cholesterol absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in removal of superoxide radicals	IEA Inferred from Electronic Annotation more info
involved_in removal of superoxide radicals	ISO Inferred from Sequence Orthology more info
involved_in response to lipid hydroperoxide	IEA Inferred from Electronic Annotation more info
involved_in response to lipid hydroperoxide	ISO Inferred from Sequence Orthology more info
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to triglyceride	IEA Inferred from Electronic Annotation more info
involved_in reverse cholesterol transport	IEA Inferred from Electronic Annotation more info
involved_in reverse cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in very-low-density lipoprotein particle remodeling	IEA Inferred from Electronic Annotation more info
involved_in very-low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
colocalizes_with cell surface	ISO Inferred from Sequence Orthology more info
part_of chylomicron	IBA Inferred from Biological aspect of Ancestor more info
part_of chylomicron	IEA Inferred from Electronic Annotation more info
part_of chylomicron	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in extracellular vesicle	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of high-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IBA Inferred from Biological aspect of Ancestor more info
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apolipoprotein A-IV

Names: apolipoprotein A4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007468.2 → NP_031494.2 apolipoprotein A-IV precursor

See identical proteins and their annotated locations for NP_031494.2

Status: VALIDATED

Source sequence(s)

AK168687, BF660098

Consensus CDS

CCDS23142.1

UniProtKB/Swiss-Prot

P06728, Q91XF8

UniProtKB/TrEMBL

Q9DBN0

Related

ENSMUSP00000034585.7, ENSMUST00000034585.7

Conserved Domains (2) summary

pfam01442
Location:66 → 235

Apolipoprotein; Apolipoprotein A1/A4/E domain

cl21528
Location:268 → 368

Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family