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    Tmprss13 transmembrane protease, serine 13 [ Mus musculus (house mouse) ]

    Gene ID: 214531, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmprss13provided by MGI
    Official Full Name
    transmembrane protease, serine 13provided by MGI
    Primary source
    MGI:MGI:2682935
    See related
    Ensembl:ENSMUSG00000037129 AllianceGenome:MGI:2682935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tpmrss13
    Summary
    Predicted to enable serine-type endopeptidase activity. Acts upstream of or within establishment of skin barrier. Predicted to be located in cytoplasm; extracellular region; and plasma membrane. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and immune system. Orthologous to human TMPRSS13 (transmembrane serine protease 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 12.6), stomach adult (RPKM 7.6) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmprss13 in Genome Data Viewer
    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (45230286..45258879)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (45318988..45347581)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene transmembrane protease, serine 4 Neighboring gene predicted gene, 57797 Neighboring gene small integral membrane protein 35 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45029701-45030002 Neighboring gene STARR-positive B cell enhancer mm9_chr9:45054121-45054422 Neighboring gene interleukin 10 receptor, alpha Neighboring gene microRNA 7086 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:45108641-45108750 Neighboring gene brown adipose tissue enriched long noncoding RNA 3 Neighboring gene STARR-seq mESC enhancer starr_23995 Neighboring gene FXYD domain-containing ion transport regulator 6 Neighboring gene predicted gene, 57798 Neighboring gene FXYD domain-containing ion transport regulator 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The cell-surface anchored serine protease TMPRSS13 promotes breast cancer progression and resistance to chemotherapy. Murray AS, et al. Oncogene, 2020 Oct. PMID 32868877, Free PMC Article
    2. TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition. Madsen DH, et al. Biochem J, 2014 Aug 1. PMID 24832573, Free PMC Article
    3. Phenotypic analysis of mice lacking the Tmprss2-encoded protease. Kim TS, et al. Mol Cell Biol, 2006 Feb. PMID 16428450, Free PMC Article
    4. Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Sherwood RI, et al. Dev Biol, 2007 Apr 15. PMID 17328885
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103261

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of skin barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protease serine 13
    Names
    membrane-type mosaic serine protease

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013373.2 → NP_001013391.2  transmembrane protease serine 13

      Status: VALIDATED

      Source sequence(s)
      AC162176, AC166051
      Consensus CDS
      CCDS23132.1
      UniProtKB/TrEMBL
      E9QPR6
      Related
      ENSMUSP00000034597.8, ENSMUST00000034597.8
      Conserved Domains (5) summary
      smart00020
      Location:306 → 535
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:307 → 535
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00530
      Location:225 → 297
      SRCR; Scavenger receptor cysteine-rich domain
      pfam15494
      Location:212 → 301
      SRCR_2; Scavenger receptor cysteine-rich domain
      cl23807
      Location:6 → 62
      WWbp; WW-domain ligand protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      45230286..45258879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510132.4 → XP_006510195.1  transmembrane protease serine 13 isoform X1

      Conserved Domains (4) summary
      smart00020
      Location:319 → 548
      Tryp_SPc; Trypsin-like serine protease
      PHA03378
      Location:6 → 122
      PHA03378; EBNA-3B; Provisional
      cd00112
      Location:204 → 220
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam15494
      Location:225 → 314
      SRCR_2; Scavenger receptor cysteine-rich domain

    2. XM_011242445.3 → XP_011240747.1  transmembrane protease serine 13 isoform X2

      Conserved Domains (4) summary
      smart00020
      Location:319 → 454
      Tryp_SPc; Trypsin-like serine protease
      PHA03378
      Location:6 → 122
      PHA03378; EBNA-3B; Provisional
      cd00112
      Location:204 → 220
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam15494
      Location:225 → 314
      SRCR_2; Scavenger receptor cysteine-rich domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U405.2 GenPept UniProtKB/Swiss-Prot:Q5U405

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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