Kcnh8 potassium voltage-gated channel, subfamily H (eag-related), member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnh8provided by MGI
Official Full Name: potassium voltage-gated channel, subfamily H (eag-related), member 8provided by MGI
Primary source: MGI:MGI:2445160
See related: Ensembl:ENSMUSG00000035580 AllianceGenome:MGI:2445160
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ELK; ELK1; ELK3; Kv12.1; C130090D05Rik
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and delayed rectifier potassium channel activity. Predicted to be involved in negative regulation of apoptotic process; potassium ion transmembrane transport; and regulation of membrane potential. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to human KCNH8 (potassium voltage-gated channel subfamily H member 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 1.5), CNS E14 (RPKM 1.3) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 C; 17 27.37 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (52909535..53286892)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (52602709..52979194)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kv12-encoded K+ channels drive the day-night switch in the repetitive firing rates of SCN neurons.
Title: Kv12-encoded K+ channels drive the day-night switch in the repetitive firing rates of SCN neurons.
Our results suggest close conformational conservation between closed EAG (Kv12.1 and Kv10.2) and Shaker family channels, despite large differences in voltage sensitivity, activation rates, and activation threshold
Title: Divalent cations slow activation of EAG family K+ channels through direct binding to S4.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1) 1 citation

General gene information

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Markers

D17Mit70 (e-PCR), detects polymorphism
- UniSTS:128100

D17Dcr14 (e-PCR), detects polymorphism
- UniSTS:507517

D17Mit6 (e-PCR), detects polymorphism
- UniSTS:116660

D17Mit139 (e-PCR), detects polymorphism
- UniSTS:116478

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-gated delayed rectifier potassium channel KCNH8; potassium voltage-gated channel subfamily H member 8

Names: ELK channel 3; ether-a-go-go-like potassium channel 3; potassium voltage-gated channel, subfamily H, member 8; voltage-gated potassium channel subunit Kv12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031811.2 → NP_001026981.2 voltage-gated delayed rectifier potassium channel KCNH8

Status: VALIDATED

Source sequence(s)

AC125051, AC131674, AK048629, BC029690, CJ165858

Consensus CDS

CCDS57101.1

UniProtKB/Swiss-Prot

P59111, Q8BX82

UniProtKB/TrEMBL

F6TUN6

Related

ENSMUSP00000049206.10, ENSMUST00000039366.11

Conserved Domains (6) summary

COG0664
Location:548 → 707

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:551 → 662

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd00130
Location:42 → 133

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00520
Location:239 → 481

Ion_trans; Ion transport protein

pfam07885
Location:421 → 475

Ion_trans_2; Ion channel

pfam13426
Location:29 → 135

PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

52909535..53286892

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160442.1 → XP_036016335.1 potassium voltage-gated channel subfamily H member 8 isoform X1

UniProtKB/Swiss-Prot

P59111, Q8BX82

Conserved Domains (3) summary

PLN03192
Location:175 → 616

PLN03192; Voltage-dependent potassium channel; Provisional

COG0664
Location:549 → 708

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

pfam13426
Location:40 → 135

PAS_9; PAS domain
XM_036160443.1 → XP_036016336.1 potassium voltage-gated channel subfamily H member 8 isoform X2

UniProtKB/Swiss-Prot

P59111, Q8BX82

Conserved Domains (3) summary

PLN03192
Location:97 → 538

PLN03192; Voltage-dependent potassium channel; Provisional

COG0664
Location:471 → 630

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

pfam13426
Location:15 → 57

PAS_9; PAS domain