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    Rgs17 regulator of G-protein signaling 17 [ Mus musculus (house mouse) ]

    Gene ID: 56533, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rgs17provided by MGI
    Official Full Name
    regulator of G-protein signaling 17provided by MGI
    Primary source
    MGI:MGI:1927469
    See related
    Ensembl:ENSMUSG00000019775 AllianceGenome:MGI:1927469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rgsz2; 6430507P11Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in several cellular components, including neuron projection; nucleus; and synapse. Orthologous to human RGS17 (regulator of G protein signaling 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 5.0), frontal lobe adult (RPKM 4.8) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rgs17 in Genome Data Viewer
    Location:
    10 A1; 10 1.91 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (5775663..5872413, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (5825663..5922412, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25595 Neighboring gene STARR-positive B cell enhancer ABC_E3873 Neighboring gene STARR-positive B cell enhancer ABC_E3872 Neighboring gene predicted gene, 53609 Neighboring gene STARR-seq mESC enhancer starr_25593 Neighboring gene mitochondrial translational release factor 1-like Neighboring gene F-box protein 5 Neighboring gene predicted gene, 18902 Neighboring gene STARR-seq mESC enhancer starr_25590 Neighboring gene STARR-seq mESC enhancer starr_25589 Neighboring gene STARR-seq mESC enhancer starr_25588 Neighboring gene STARR-seq mESC enhancer starr_25586 Neighboring gene STARR-seq mESC enhancer starr_25585 Neighboring gene STARR-seq mESC enhancer starr_25584 Neighboring gene predicted gene 3213 Neighboring gene tripartite motif-containing 59 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SUMO-SIM interactions regulate the activity of RGSZ2 proteins. Garzón J, et al. PLoS One, 2011. PMID 22163035, Free PMC Article
    2. RGSZ2 binds to the neural nitric oxide synthase PDZ domain to regulate mu-opioid receptor-mediated potentiation of the N-methyl-D-aspartate receptor-calmodulin-dependent protein kinase II pathway. Garzón J, et al. Antioxid Redox Signal, 2011 Aug 15. PMID 21348811
    3. RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling. Mao H, et al. J Biol Chem, 2004 Jun 18. PMID 15096504
    4. NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors. Rodríguez-Muñoz M, et al. Cell Signal, 2008 Oct. PMID 18652891
    5. The Axonal Motor Neuropathy-Related HINT1 Protein Is a Zinc- and Calmodulin-Regulated Cysteine SUMO Protease. Cortés-Montero E, et al. Antioxid Redox Signal, 2019 Sep 1. PMID 31088288, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUMO-SIM interactions regulate the activity of RGSZ2 proteins
      Title: SUMO-SIM interactions regulate the activity of RGSZ2 proteins.
    2. This RGSZ2-dependent regulation of NMDAR activity is relevant to persistent pain disorders associated with heightened NMDAR-mediated glutamate responses and the reduced antinociceptive capacity of opioids.
      Title: RGSZ2 binds to the neural nitric oxide synthase PDZ domain to regulate mu-opioid receptor-mediated potentiation of the N-methyl-D-aspartate receptor-calmodulin-dependent protein kinase II pathway.
    3. These results indicate that the NMDAR/nNOS cascade, activated via MORs, provide the free zinc ions required for inactive PKCgamma to bind to HINT1/RGSZ complex at the C terminus of the receptor.
      Title: NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 17
    Names
    regulator of G-protein signaling Z2
    regulator of Gz-selective protein signaling 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161822.1 → NP_001155294.1  regulator of G-protein signaling 17 isoform 1

      See identical proteins and their annotated locations for NP_001155294.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC159325, AK030492, AK045770
      Consensus CDS
      CCDS56686.1
      UniProtKB/TrEMBL
      G5E8E0, Q8BR34
      Related
      ENSMUSP00000065825.8, ENSMUST00000064225.14
      Conserved Domains (1) summary
      cl02565
      Location:61 → 217
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. NM_019958.4 → NP_064342.1  regulator of G-protein signaling 17 isoform 2

      See identical proteins and their annotated locations for NP_064342.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks the exon containing the translation start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC159325, AK030492
      Consensus CDS
      CCDS56685.1
      UniProtKB/Swiss-Prot
      Q543T9, Q9QZB0
      UniProtKB/TrEMBL
      Q8C5F3
      Related
      ENSMUSP00000116291.2, ENSMUST00000131996.8
      Conserved Domains (1) summary
      cl02565
      Location:41 → 197
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      5775663..5872413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512457.5 → XP_006512520.1  regulator of G-protein signaling 17 isoform X2

      See identical proteins and their annotated locations for XP_006512520.1

      UniProtKB/Swiss-Prot
      Q543T9, Q9QZB0
      UniProtKB/TrEMBL
      Q8C5F3
      Conserved Domains (1) summary
      cl02565
      Location:41 → 197
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. XM_030245185.2 → XP_030101045.1  regulator of G-protein signaling 17 isoform X1

      UniProtKB/TrEMBL
      G5E8E0, Q8BR34
      Conserved Domains (1) summary
      cl02565
      Location:61 → 217
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZB0.1 GenPept UniProtKB/Swiss-Prot:Q9QZB0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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