Nradd neurotrophin receptor associated death domain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nraddprovided by MGI
Official Full Name: neurotrophin receptor associated death domainprovided by MGI
Primary source: MGI:MGI:1914419
See related: Ensembl:ENSMUSG00000032491 AllianceGenome:MGI:1914419
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NRDD; NRH2; PLAIDD; 2610311B09Rik
Summary: Predicted to enable several functions, including coreceptor activity; nerve growth factor binding activity; and neurotrophin p75 receptor binding activity. Predicted to be involved in Rho protein signal transduction. Located in lamellipodium; membrane; and nuclear envelope lumen. Is expressed in dorsal root ganglion; medulla oblongata; retina layer; and spinal cord. Orthologous to human NRADDP (neurotrophin receptor associated death domain, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in ovary adult (RPKM 18.1), limb E14.5 (RPKM 13.0) and 21 other tissues See more
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Genomic context

Location:: 9 F2; 9 60.26 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (110450203..110453461, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (110621135..110624393, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The NRADD conditional and complete knockout mouse lines generated are new and useful tools to study the physiological roles of NRADD.
Title: Generation and characterization of mice bearing null alleles of nradd/Nrh2.
Its reduction ameliorates cognitive deficits in Alzheimer disease.
Title: Reduction of p75 neurotrophin receptor ameliorates the cognitive deficits in a model of Alzheimer's disease.
These results suggest a mechanism involving both the transmembrane domain and the death domain of p45 to regulate p75-mediated signaling.
Title: Heterodimerization of p45-p75 modulates p75 signaling: structural basis and mechanism of action.
p45 forms a complex with FADD and diminishes Fas-FADD mediated death signaling.
Title: P45 forms a complex with FADD and promotes neuronal cell survival following spinal cord injury.
The authors show that the mammalian p75NTR homologue NRH2 critically regulates the expression of sortilin on the neuronal cell surface and promotes p75NTR and sortilin receptor complex formation, rendering cells responsive to proneurotrophins.
Title: NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables coreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables death receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nerve growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurotrophin p75 receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell body membrane	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope lumen	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: death domain-containing membrane protein NRADD

Names: neurotrophin receptor homolog-2; neurotrophin receptor-alike death domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026012.2 → NP_080288.1 death domain-containing membrane protein NRADD

See identical proteins and their annotated locations for NP_080288.1

Status: PROVISIONAL

Source sequence(s)

BC069856

Consensus CDS

CCDS23569.1

UniProtKB/Swiss-Prot

Q3TVC1, Q8CJ26

UniProtKB/TrEMBL

A0A0G2JH13

Related

ENSMUSP00000035069.10, ENSMUST00000035069.14

Conserved Domains (2) summary

cd08311
Location:138 → 219

Death_p75NR; Death domain of p75 Neurotrophin Receptor

pfam10883
Location:59 → 88

DUF2681; Protein of unknown function (DUF2681)