IL1B interleukin 1 beta [Sus scrofa (pig)] - Gene

Summary

Gene symbol: IL1B
Gene description: interleukin 1 beta
See related: Ensembl:ENSSSCG00000039214
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: IL1B1
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	3	NC_010445.4 (43670126..43677125)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	3	NC_010445.3 (45319296..45326287, complement)

Chromosome 3 - NC_010445.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FMDV Leader Protein Interacts with the NACHT and LRR Domains of NLRP3 to Promote IL-1beta Production.
Title: FMDV Leader Protein Interacts with the NACHT and LRR Domains of NLRP3 to Promote IL-1β Production.
Porcine Circovirus Type 2 Induces Single Immunoglobulin Interleukin-1 Related Receptor (SIGIRR) Downregulation to Promote Interleukin-1beta Upregulation in Porcine Alveolar Macrophage.
Title: Porcine Circovirus Type 2 Induces Single Immunoglobulin Interleukin-1 Related Receptor (SIGIRR) Downregulation to Promote Interleukin-1β Upregulation in Porcine Alveolar Macrophage.
This study provides evidence that IL-1beta combined with IL-17A promoted chronic inflammatory arthritis by activating the catabolic processes accompanied with the suppression of cartilage anabolism. These suggest that further applications, which suppress inflammatory enhancers, especially IL-17A, should be considered as a target for arthritis research and therapy.
Title: Proinflammatory Effects of IL-1β Combined with IL-17A Promoted Cartilage Degradation and Suppressed Genes Associated with Cartilage Matrix Synthesis In Vitro.
These studies showed that classical swine fever virus-induced IL-1beta secretion was mediated by NLRP3 and that classical swine fever virus infection could sufficiently activate the assembly of the NLRP3 inflammasome in monocytes.
Title: Activation of Interleukin-1β Release by the Classical Swine Fever Virus Is Dependent on the NLRP3 Inflammasome, Which Affects Virus Growth in Monocytes.
Hsp90/Sec22b promotes the unconventional secretion of IL-1beta through an autophagosomal carrier during Mycoplasma hyopneumoniae infection.
Title: Hsp90/Sec22b promotes unconventional secretion of mature-IL-1β through an autophagosomal carrier in porcine alveolar macrophages during Mycoplasma hyopneumoniae infection.
Data indicated that Porcine reproductive and respiratory syndrome virus infection could induce IL-1beta up-regulation, which was likely mediated by MyD88/ERK/AP-1 and NLRP3 inflammasome.
Title: Porcine reproductive and respiratory syndrome virus induces interleukin-1β through MyD88/ERK/AP-1 and NLRP3 inflammasome in microglia.
Analysis of host-protein interactions for African swine fever virus L83L identified IL-1beta as its host ligand. A recombinant African swine fever virus lacking the L83L was developed from the highly virulent field isolate Georgia2007 and was used to show that L83L is a non-essential gene.
Title: The L83L ORF of African swine fever virus strain Georgia encodes for a non-essential gene that interacts with the host protein IL-1β.
This study showed that the presence of embryos in oviducts on days 2-3 after mating may influence the oviductal expression of the members of the IL-1beta system, determining the action of IL-1beta, which may be considered to be the earliest sign of pregnancy in pigs.
Title: Interleukin-1β system in the oviducts of pigs during the oestrous cycle and early pregnancy.
This study showed that classical swine fever virus and p7 protein induced IL-1beta secretion and that p7 protein was a short-lived protein degraded by the proteasome.
Title: Classical swine fever virus and p7 protein induce secretion of IL-1β in macrophages.
local expression of IL-1beta and IL-8 in non-bacterial thrombotic endocarditis, Staphylococcus aureus infective endocarditis, animals with S. aureus sepsis without endocarditis and controls
Title: Systemic inflammatory response and local cytokine expression in porcine models of endocarditis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables interleukin-1 receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of immature T cell proliferation in thymus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of nitric-oxide synthase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-1 beta

Names: IL-1 beta; interleukin 1, beta 1; prointerleukin-1 beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214055.1 → NP_999220.1 interleukin-1 beta

See identical proteins and their annotated locations for NP_999220.1

Status: PROVISIONAL

Source sequence(s)

M86725

UniProtKB/Swiss-Prot

P26889

UniProtKB/TrEMBL

A0A8D1KFH7, A0A8D1P493

Related

ENSSSCP00000044922.1, ENSSSCT00000062058.3

Conserved Domains (2) summary

smart00125
Location:117 → 263

IL1; Interleukin-1 homologues

pfam02394
Location:1 → 101

IL1_propep; Interleukin-1 propeptide

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010445.4 Reference Sscrofa11.1 Primary Assembly

Range

43670126..43677125

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021085847.1 → XP_020941506.1 interleukin-1 beta isoform X1

UniProtKB/TrEMBL

A0A8D0QSX4

Conserved Domains (2) summary

smart00125
Location:132 → 278

IL1; Interleukin-1 homologues

pfam02394
Location:16 → 116

IL1_propep; Interleukin-1 propeptide