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    Mok MOK protein kinase [ Mus musculus (house mouse) ]

    Gene ID: 26448, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mokprovided by MGI
    Official Full Name
    MOK protein kinaseprovided by MGI
    Primary source
    MGI:MGI:1336881
    See related
    Ensembl:ENSMUSG00000056458 AllianceGenome:MGI:1336881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rage; RAGE1; Stk30
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Located in ciliary base and nucleus. Is expressed in brain; gonad; heart; liver; and metanephros. Orthologous to human MOK (MOK protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 13.5), CNS E18 (RPKM 1.7) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mok in Genome Data Viewer
    Location:
    12 F1; 12 60.81 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (110770404..110807391, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (110807798..110840962, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53768 Neighboring gene STARR-positive B cell enhancer mm9_chr12:111934512-111934812 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111945270-111945457 Neighboring gene STARR-seq mESC enhancer starr_33300 Neighboring gene STARR-seq mESC enhancer starr_33301 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:111976119-111976302 Neighboring gene WD repeat domain 20 Neighboring gene STARR-seq mESC enhancer starr_33302 Neighboring gene STARR-positive B cell enhancer ABC_E5355 Neighboring gene STARR-seq mESC enhancer starr_33307 Neighboring gene RIKEN cDNA 4921507G05 gene Neighboring gene STARR-positive B cell enhancer ABC_E5356 Neighboring gene STARR-positive B cell enhancer ABC_E1865 Neighboring gene STARR-positive B cell enhancer ABC_E4044 Neighboring gene nuclear encoded tRNA isoleucine 6 (anticodon AAT)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection. Lutterloh EC, et al. Crit Care, 2007. PMID 18042296, Free PMC Article
    2. MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS. Pérez-Cabello JA, et al. Proc Natl Acad Sci U S A, 2023 Jul 11. PMID 37399380, Free PMC Article
    3. Long-term renal effects of a neutralizing RAGE antibody in obese type 2 diabetic mice. Flyvbjerg A, et al. Diabetes, 2004 Jan. PMID 14693711
    4. Regulation of osteoclast function and bone mass by RAGE. Zhou Z, et al. J Exp Med, 2006 Apr 17. PMID 16606672, Free PMC Article
    5. Diabetes, leukoencephalopathy and rage. Toth C, et al. Neurobiol Dis, 2006 Aug. PMID 16815028

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential expression of SLC30A10 and RAGE in mouse pups by early life lead exposure.
      Title: Differential expression of SLC30A10 and RAGE in mouse pups by early life lead exposure.
    2. MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS.
      Title: MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS.
    3. This provides new insight into the immune phenotype, mechanisms, and signaling pathways that operate in microglial neurotoxic activation in amyotrophic lateral sclerosis.
      Title: Extracellular TDP-43 aggregates target MAPK/MAK/MRK overlapping kinase (MOK) and trigger caspase-3/IL-18 signaling in microglia.
    4. the expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases.
      Title: Distinct expression patterns of ICK/MAK/MOK protein kinases in the intestine implicate functional diversity.
    5. Suppression of Egr-1 may contribute to the protective mechanisms underlying the beneficial impact of RAGE blockade or deletion in hepatic ischemia/reperfusion injury.
      Title: Receptor for advanced glycation end product (RAGE)-dependent modulation of early growth response-1 in hepatic ischemia/reperfusion injury.
    6. RAGE inactivation inhibits the atherosclerosis through reducing oxLDL-induced pro-inflammatory responses and oxidative stress in hyperlipidaemia.
      Title: RAGE mediates oxidized LDL-induced pro-inflammatory effects and atherosclerosis in non-diabetic LDL receptor-deficient mice.
    7. identification of MOK, a member of the mitogen-activated protein kinase superfamily, as one of the genes induced by a caudal-related homeobox transcription factor, Cdx2
      Title: Cdx2 homeodomain protein regulates the expression of MOK, a member of the mitogen-activated protein kinase superfamily, in the intestinal epithelial cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC46883, MGC107277

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary base IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAPK/MAK/MRK overlapping kinase
    Names
    T/STK 30
    renal tumor antigen
    serine/threonine kinase 30
    NP_001404448.1
    NP_001404449.1
    NP_001404450.1
    NP_001404451.1
    NP_001404452.1
    NP_001404453.1
    NP_001404454.1
    NP_001404455.1
    NP_001404456.1
    NP_001404457.1
    NP_001404458.1
    NP_001404459.1
    NP_001404460.1
    NP_001404461.1
    NP_001404462.1
    NP_001404463.1
    NP_001404464.1
    NP_001404465.1
    NP_001404466.1
    NP_001410418.1
    NP_036103.1
    XP_006515949.1
    XP_006515953.1
    XP_006515955.1
    XP_017170559.1
    XP_017170560.1
    XP_030102571.1
    XP_030102576.1
    XP_030102578.1
    XP_030102583.1
    XP_030102585.1
    XP_036013304.1
    XP_036013305.1
    XP_036013306.1
    XP_036013308.1
    XP_036013310.1
    XP_036013311.1
    XP_036013313.1
    XP_036013315.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417519.1 → NP_001404448.1  MAPK/MAK/MRK overlapping kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    2. NM_001417520.1 → NP_001404449.1  MAPK/MAK/MRK overlapping kinase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    3. NM_001417521.1 → NP_001404450.1  MAPK/MAK/MRK overlapping kinase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    4. NM_001417522.1 → NP_001404451.1  MAPK/MAK/MRK overlapping kinase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    5. NM_001417523.1 → NP_001404452.1  MAPK/MAK/MRK overlapping kinase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    6. NM_001417524.1 → NP_001404453.1  MAPK/MAK/MRK overlapping kinase isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    7. NM_001417525.1 → NP_001404454.1  MAPK/MAK/MRK overlapping kinase isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265
      UniProtKB/TrEMBL
      Q5M8P5
      Related
      ENSMUSP00000082041.5, ENSMUST00000084974.11

    8. NM_001417526.1 → NP_001404455.1  MAPK/MAK/MRK overlapping kinase isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    9. NM_001417527.1 → NP_001404456.1  MAPK/MAK/MRK overlapping kinase isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    10. NM_001417528.1 → NP_001404457.1  MAPK/MAK/MRK overlapping kinase isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    11. NM_001417529.1 → NP_001404458.1  MAPK/MAK/MRK overlapping kinase isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    12. NM_001417530.1 → NP_001404459.1  MAPK/MAK/MRK overlapping kinase isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    13. NM_001417531.1 → NP_001404460.1  MAPK/MAK/MRK overlapping kinase isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    14. NM_001417532.1 → NP_001404461.1  MAPK/MAK/MRK overlapping kinase isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    15. NM_001417533.1 → NP_001404462.1  MAPK/MAK/MRK overlapping kinase isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    16. NM_001417534.1 → NP_001404463.1  MAPK/MAK/MRK overlapping kinase isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    17. NM_001417535.1 → NP_001404464.1  MAPK/MAK/MRK overlapping kinase isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    18. NM_001417536.1 → NP_001404465.1  MAPK/MAK/MRK overlapping kinase isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    19. NM_001417537.1 → NP_001404466.1  MAPK/MAK/MRK overlapping kinase isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    20. NM_001423489.1 → NP_001410418.1  MAPK/MAK/MRK overlapping kinase isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    21. NM_011973.3 → NP_036103.1  MAPK/MAK/MRK overlapping kinase isoform 1

      See identical proteins and their annotated locations for NP_036103.1

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265
      Consensus CDS
      CCDS49176.1
      UniProtKB/Swiss-Prot
      Q8CFU4, Q9WVS4
      Related
      ENSMUSP00000068904.9, ENSMUST00000070565.15
      Conserved Domains (2) summary
      smart00220
      Location:4 → 285
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07831
      Location:4 → 285
      STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

    RNA

    1. NR_184527.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC101875, AL596265

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      110770404..110807391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157412.1 → XP_036013305.1  MAPK/MAK/MRK overlapping kinase isoform X11

      Conserved Domains (1) summary
      cl21453
      Location:1 → 193
      PKc_like; Protein Kinases, catalytic domain

    2. XM_030246711.2 → XP_030102571.1  MAPK/MAK/MRK overlapping kinase isoform X6

      Conserved Domains (1) summary
      cd07831
      Location:4 → 234
      STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

    3. XM_006515886.3 → XP_006515949.1  MAPK/MAK/MRK overlapping kinase isoform X2

      Conserved Domains (1) summary
      cd07831
      Location:4 → 285
      STKc_MOK; Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase

    4. XM_006515892.3 → XP_006515955.1  MAPK/MAK/MRK overlapping kinase isoform X12

      See identical proteins and their annotated locations for XP_006515955.1

      Conserved Domains (1) summary
      cl21453
      Location:3 → 180
      PKc_like; Protein Kinases, catalytic domain

    5. XM_030246718.2 → XP_030102578.1  MAPK/MAK/MRK overlapping kinase isoform X17

      Conserved Domains (1) summary
      cl21453
      Location:1 → 150
      PKc_like; Protein Kinases, catalytic domain

    6. XM_036157411.1 → XP_036013304.1  MAPK/MAK/MRK overlapping kinase isoform X8

      Conserved Domains (1) summary
      cl21453
      Location:1 → 201
      PKc_like; Protein Kinases, catalytic domain

    7. XM_030246723.2 → XP_030102583.1  MAPK/MAK/MRK overlapping kinase isoform X19

      Conserved Domains (1) summary
      cl21453
      Location:3 → 129
      PKc_like; Protein Kinases, catalytic domain

    8. XM_036157420.1 → XP_036013313.1  MAPK/MAK/MRK overlapping kinase isoform X21

      Conserved Domains (1) summary
      cl21453
      Location:3 → 129
      PKc_like; Protein Kinases, catalytic domain

    9. XM_036157418.1 → XP_036013311.1  MAPK/MAK/MRK overlapping kinase isoform X19

      Conserved Domains (1) summary
      cl21453
      Location:3 → 129
      PKc_like; Protein Kinases, catalytic domain

    10. XM_036157413.1 → XP_036013306.1  MAPK/MAK/MRK overlapping kinase isoform X12

      Conserved Domains (1) summary
      cl21453
      Location:3 → 180
      PKc_like; Protein Kinases, catalytic domain

    11. XM_036157422.1 → XP_036013315.1  MAPK/MAK/MRK overlapping kinase isoform X22

      Conserved Domains (1) summary
      cl21453
      Location:3 → 129
      PKc_like; Protein Kinases, catalytic domain

    12. XM_030246725.2 → XP_030102585.1  MAPK/MAK/MRK overlapping kinase isoform X20

      Conserved Domains (1) summary
      cl21453
      Location:1 → 150
      PKc_like; Protein Kinases, catalytic domain

    13. XM_030246716.2 → XP_030102576.1  MAPK/MAK/MRK overlapping kinase isoform X14

      Conserved Domains (1) summary
      cl21453
      Location:1 → 150
      PKc_like; Protein Kinases, catalytic domain

    14. XM_036157417.1 → XP_036013310.1  MAPK/MAK/MRK overlapping kinase isoform X18

      Conserved Domains (1) summary
      cl21453
      Location:3 → 129
      PKc_like; Protein Kinases, catalytic domain

    15. XM_036157415.1 → XP_036013308.1  MAPK/MAK/MRK overlapping kinase isoform X14

      Conserved Domains (1) summary
      cl21453
      Location:1 → 150
      PKc_like; Protein Kinases, catalytic domain

    16. XM_017315070.1 → XP_017170559.1  MAPK/MAK/MRK overlapping kinase isoform X8

      Conserved Domains (1) summary
      cl21453
      Location:1 → 201
      PKc_like; Protein Kinases, catalytic domain

    17. XM_017315071.3 → XP_017170560.1  MAPK/MAK/MRK overlapping kinase isoform X8

      Conserved Domains (1) summary
      cl21453
      Location:1 → 201
      PKc_like; Protein Kinases, catalytic domain

    18. XM_006515890.5 → XP_006515953.1  MAPK/MAK/MRK overlapping kinase isoform X9

      Conserved Domains (1) summary
      cl21453
      Location:8 → 198
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_003950050.2 RNA Sequence

    2. XR_003950051.2 RNA Sequence

    3. XR_003950052.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_184528.1: Suppressed sequence

      Description
      NR_184528.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVS4.1 GenPept UniProtKB/Swiss-Prot:Q9WVS4

    Gene LinkOut

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