Cntnap2 contactin associated protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cntnap2provided by RGD
Official Full Name: contactin associated protein 2provided by RGD
Primary source: RGD:1307076
See related: EnsemblRapid:ENSRNOG00000006617 AllianceGenome:RGD:1307076
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protease binding activity and transmembrane transporter binding activity. Involved in prepulse inhibition. Located in several cellular components, including main axon; neuronal cell body; and synaptic membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic membrane. Used to study autism spectrum disorder and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including Pitt-Hopkins syndrome; autism spectrum disorder (multiple); communication disorder (multiple); cortical dysplasia-focal epilepsy syndrome; and social phobia. Orthologous to human CNTNAP2 (contactin associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 151.1), Testes (RPKM 25.1) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (75109358..77366258)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (74109455..76366434)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (74700539..77025463)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Assessing the Cntnap2 knockout rat prepulse inhibition deficit through prepulse scaling of the baseline startle response curve.
Title: Assessing the Cntnap2 knockout rat prepulse inhibition deficit through prepulse scaling of the baseline startle response curve.
Developmental changes in electrophysiological properties of auditory cortical neurons in the Cntnap2 knockout rat.
Title: Developmental changes in electrophysiological properties of auditory cortical neurons in the Cntnap2 knockout rat.
Hyperexcitable and immature-like neuronal activity in the auditory cortex of adult rats lacking the language-linked CNTNAP2 gene.
Title: Hyperexcitable and immature-like neuronal activity in the auditory cortex of adult rats lacking the language-linked CNTNAP2 gene.
Study shows altered auditory processing, filtering, and reactivity in the Cntnap2 knock-out rat model for neurodevelopmental disorders.
Title: Altered Auditory Processing, Filtering, and Reactivity in the Cntnap2 Knock-Out Rat Model for Neurodevelopmental Disorders.
Cntnap2 KO rats exhibited severe motor seizures, hyperactivity, and increased consolidation of wakefulness and REM sleep. By contrast, Cntnap2 KO mice demonstrated absence seizure-like events, hypoactivity, and wake fragmentation.
Title: Cntnap2 Knockout Rats and Mice Exhibit Epileptiform Activity and Abnormal Sleep-Wake Physiology.
In situ and biochemical analyses reported herein that confirm expression in relevant brain regions and demonstrate the presence of CNTNAP2 in the synaptic plasma membrane fraction of rat forebrain lysates.
Title: Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Got55 (e-PCR)
- UniSTS:112897

RH142692 (e-PCR)
- UniSTS:231939

BE095511 (e-PCR)
- UniSTS:243467

G46753 (e-PCR)
- UniSTS:107550

RH138106 (e-PCR)
- UniSTS:220193

AW523771 (e-PCR)
- UniSTS:244009

D4Rat29 (e-PCR), detects polymorphism
- UniSTS:118830

D4Rat30 (e-PCR), detects polymorphism
- UniSTS:118832

D4Rat31 (e-PCR)
- UniSTS:118833

d4arb30 (e-PCR)
- UniSTS:121913

GDB:1318422 (e-PCR)
- UniSTS:42043

px-50f10 (e-PCR)
- UniSTS:257885

D4Got56 (e-PCR)
- UniSTS:114019

AU026952 (e-PCR)
- UniSTS:113774

d4mgh24 (e-PCR)
- UniSTS:120434

d4rat164 (e-PCR)
- UniSTS:121976

AU049338 (e-PCR)
- UniSTS:145786

AU029040 (e-PCR)
- UniSTS:111753

D4Got57 (e-PCR)
- UniSTS:114571

D4RAT32 (e-PCR)
- UniSTS:122004

D4Rat213 (e-PCR), detects polymorphism
- UniSTS:227760

D4Got53 (e-PCR)
- UniSTS:112072

RH137515 (e-PCR)
- UniSTS:219603

D4Got54 (e-PCR)
- UniSTS:114140

D4Rat263 (e-PCR)
- UniSTS:227806

AU048430 (e-PCR)
- UniSTS:144880

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in action potential initiation	ISO Inferred from Sequence Orthology more info
involved_in adult behavior	ISO Inferred from Sequence Orthology more info
involved_in associative learning	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in behavioral response to pain	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in central nervous system myelination	ISO Inferred from Sequence Orthology more info
involved_in cerebellar Purkinje cell layer morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cerebellum development	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in circadian sleep/wake cycle	ISO Inferred from Sequence Orthology more info
involved_in clustering of voltage-gated potassium channels	ISO Inferred from Sequence Orthology more info
involved_in dendrite arborization	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in dendritic spine organization	ISO Inferred from Sequence Orthology more info
involved_in embryonic brain development	ISO Inferred from Sequence Orthology more info
involved_in excitatory chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in excitatory synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in glial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glutamatergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in grooming behavior	ISO Inferred from Sequence Orthology more info
involved_in in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inhibitory chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in inhibitory synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in limbic system development	ISO Inferred from Sequence Orthology more info
involved_in locomotor rhythm	ISO Inferred from Sequence Orthology more info
involved_in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in maintenance of synapse structure	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in motor behavior	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, GABAergic	ISO Inferred from Sequence Orthology more info
involved_in neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular junction development, skeletal muscle fiber	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling posture	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gap junction assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic density organization	ISO Inferred from Sequence Orthology more info
involved_in prepulse inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
involved_in protein localization to juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	ISO Inferred from Sequence Orthology more info
involved_in response to dietary excess	ISO Inferred from Sequence Orthology more info
involved_in response to heat	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-17	ISO Inferred from Sequence Orthology more info
involved_in response to light intensity	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to metformin	ISO Inferred from Sequence Orthology more info
involved_in response to odorant	ISO Inferred from Sequence Orthology more info
involved_in response to pain	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in rhythmic behavior	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in startle response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in striatum development	ISO Inferred from Sequence Orthology more info
involved_in superior temporal gyrus development	ISO Inferred from Sequence Orthology more info
involved_in thalamus development	ISO Inferred from Sequence Orthology more info
involved_in transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in vocal learning	ISO Inferred from Sequence Orthology more info
involved_in vocalization behavior	ISO Inferred from Sequence Orthology more info
involved_in walking behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in axolemma	IDA Inferred from Direct Assay more info	PubMed
located_in axolemma	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in axon initial segment	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in cerebellar granule cell to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in excitatory synapse	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in juxtaparanode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	ISO Inferred from Sequence Orthology more info
is_active_in neuron spine	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in paranodal junction	IEA Inferred from Electronic Annotation more info
located_in paranode region of axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: contactin-associated protein-like 2

Names: contactin associated protein-like 2; mKIAA0868 protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427648.1 → NP_001414577.1 contactin-associated protein-like 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A8I6GH02

Related

ENSRNOP00000088343.1, ENSRNOT00000008688.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

75109358..77366258

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109027.2 → XP_038964955.1 contactin-associated protein-like 2 isoform X1

Conserved Domains (6) summary

smart00294
Location:779 → 797

4.1m; putative band 4.1 homologues' binding motif

cd00054
Location:51 → 86

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:296 → 439

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:463 → 488

EGF; EGF-like domain

pfam02210
Location:552 → 684

Laminin_G_2; Laminin G domain

cl02436
Location:105 → 128

COLFI; Fibrillar collagen C-terminal domain
XM_039109028.2 → XP_038964956.1 contactin-associated protein-like 2 isoform X1

Conserved Domains (6) summary

smart00294
Location:779 → 797

4.1m; putative band 4.1 homologues' binding motif

cd00054
Location:51 → 86

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:296 → 439

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam00008
Location:463 → 488

EGF; EGF-like domain

pfam02210
Location:552 → 684

Laminin_G_2; Laminin G domain

cl02436
Location:105 → 128

COLFI; Fibrillar collagen C-terminal domain