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    BRD10 bromodomain containing 10 [ Homo sapiens (human) ]

    Gene ID: 158358, updated on 27-Nov-2024

    Summary

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    Official Symbol
    BRD10provided by HGNC
    Official Full Name
    bromodomain containing 10provided by HGNC
    Primary source
    HGNC:HGNC:23378
    See related
    Ensembl:ENSG00000183354 AllianceGenome:HGNC:23378
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA2026
    Summary
    Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 4.2), thyroid (RPKM 2.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BRD10 in Genome Data Viewer
    Location:
    9p24.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (5878834..6008482, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (5881968..6013620, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (5919022..6008482, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RIC1 homolog, RAB6A GEF complex partner 1 Neighboring gene uncharacterized LOC124902115 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:5762408-5763607 Neighboring gene endoplasmic reticulum metallopeptidase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19756 Neighboring gene Sharpr-MPRA regulatory region 2314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19757 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:5879621-5880122 Neighboring gene small nucleolar RNA U13 Neighboring gene adenylate kinase 4 pseudogene 4 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:5909826-5911025 Neighboring gene melan-A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19759 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:6007511-6008012 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:6008013-6008512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19762 Neighboring gene microRNA 4665 Neighboring gene RAN binding protein 6 Neighboring gene uncharacterized LOC124902116

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Writers and readers of histone acetylation: structure, mechanism, and inhibition. Marmorstein R, et al. Cold Spring Harb Perspect Biol, 2014 Jul 1. PMID 24984779, Free PMC Article
    2. The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. Uhler JP, et al. Biochem Biophys Res Commun, 2014 Jan 3. PMID 24211586
    3. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Vizeacoumar FJ, et al. Mol Syst Biol, 2013 Oct 8. PMID 24104479, Free PMC Article
    4. SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9. Schmidt N, et al. Cell, 2023 Oct 26. PMID 37794589, Free PMC Article
    5. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized bromodomain-containing protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017969.3 → NP_001017969.2  uncharacterized bromodomain-containing protein 10

      See identical proteins and their annotated locations for NP_001017969.2

      Status: VALIDATED

      Source sequence(s)
      AL162384, AL365360, BC108654, DY655479
      UniProtKB/Swiss-Prot
      A8MTP2, B9EGW7, Q4VXA2, Q5HYC2, Q8IVE5
      Related
      ENSP00000382815.3, ENST00000399933.8
      Conserved Domains (3) summary
      cd04369
      Location:137 → 193
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
      pfam05672
      Location:253 → 292
      MAP7; MAP7 (E-MAP-115) family
      pfam06936
      Location:225 → 287
      Selenoprotein_S; Selenoprotein S (SelS)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      5878834..6008482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517760.4 → XP_011516062.1  uncharacterized bromodomain-containing protein 10 isoform X3

      See identical proteins and their annotated locations for XP_011516062.1

      Conserved Domains (4) summary
      cd04369
      Location:137 → 193
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
      PHA03255
      Location:1668 → 1825
      PHA03255; BDLF3; Provisional
      pfam05109
      Location:1180 → 1760
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam06936
      Location:225 → 287
      Selenoprotein_S; Selenoprotein S (SelS)

    2. XM_011517759.4 → XP_011516061.1  uncharacterized bromodomain-containing protein 10 isoform X3

      See identical proteins and their annotated locations for XP_011516061.1

      Conserved Domains (4) summary
      cd04369
      Location:137 → 193
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
      PHA03255
      Location:1668 → 1825
      PHA03255; BDLF3; Provisional
      pfam05109
      Location:1180 → 1760
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam06936
      Location:225 → 287
      Selenoprotein_S; Selenoprotein S (SelS)

    3. XM_047422861.1 → XP_047278817.1  uncharacterized bromodomain-containing protein 10 isoform X6

    4. XM_017014331.3 → XP_016869820.1  uncharacterized bromodomain-containing protein 10 isoform X2

    5. XM_005251385.4 → XP_005251442.1  uncharacterized bromodomain-containing protein 10 isoform X1

      UniProtKB/Swiss-Prot
      Q5HYC2
      Related
      ENSP00000370870.2, ENST00000381461.6
      Conserved Domains (3) summary
      cd04369
      Location:137 → 193
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
      pfam05672
      Location:253 → 292
      MAP7; MAP7 (E-MAP-115) family
      pfam06936
      Location:225 → 287
      Selenoprotein_S; Selenoprotein S (SelS)

    6. XM_047422860.1 → XP_047278816.1  uncharacterized bromodomain-containing protein 10 isoform X5

    7. XM_024447429.2 → XP_024303197.1  uncharacterized bromodomain-containing protein 10 isoform X4

    8. XM_011517761.3 → XP_011516063.1  uncharacterized bromodomain-containing protein 10 isoform X5

      See identical proteins and their annotated locations for XP_011516063.1

      UniProtKB/Swiss-Prot
      Q5HYC2

    9. XM_047422862.1 → XP_047278818.1  uncharacterized bromodomain-containing protein 10 isoform X7

    RNA

    1. XR_007061251.1 RNA Sequence

    2. XR_007061249.1 RNA Sequence

    3. XR_007061250.1 RNA Sequence

    4. XR_007061252.1 RNA Sequence

    5. XR_001746198.3 RNA Sequence

    6. XR_001746203.3 RNA Sequence

    7. XR_001746207.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      5881968..6013620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362141.1 → XP_054218116.1  uncharacterized bromodomain-containing protein 10 isoform X3

    2. XM_054362145.1 → XP_054218120.1  uncharacterized bromodomain-containing protein 10 isoform X6

    3. XM_054362140.1 → XP_054218115.1  uncharacterized bromodomain-containing protein 10 isoform X1

    4. XM_054362143.1 → XP_054218118.1  uncharacterized bromodomain-containing protein 10 isoform X5

    5. XM_054362142.1 → XP_054218117.1  uncharacterized bromodomain-containing protein 10 isoform X4

    6. XM_054362144.1 → XP_054218119.1  uncharacterized bromodomain-containing protein 10 isoform X5

    7. XM_054362146.1 → XP_054218121.1  uncharacterized bromodomain-containing protein 10 isoform X7

    RNA

    1. XR_008487947.1 RNA Sequence

    2. XR_008487946.1 RNA Sequence

    3. XR_008487948.1 RNA Sequence

    4. XR_008487949.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HYC2.2 GenPept UniProtKB/Swiss-Prot:Q5HYC2

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