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    AFAP1L2 actin filament associated protein 1 like 2 [ Homo sapiens (human) ]

    Gene ID: 84632, updated on 27-Nov-2024

    Summary

    Official Symbol
    AFAP1L2provided by HGNC
    Official Full Name
    actin filament associated protein 1 like 2provided by HGNC
    Primary source
    HGNC:HGNC:25901
    See related
    Ensembl:ENSG00000169129 MIM:612420; AllianceGenome:HGNC:25901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    XB130; KIAA1914; CTB-1144G6.4
    Summary
    Enables SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; regulation of gene expression; and regulation of mitotic cell cycle. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thyroid (RPKM 34.2), spleen (RPKM 23.9) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See AFAP1L2 in Genome Data Viewer
    Location:
    10q25.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (114280725..114405175, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (115174841..115299200, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (116054583..116164261, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene tudor domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:115998924-115999632 Neighboring gene MPRA-validated peak1096 silencer Neighboring gene MPRA-validated peak1097 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116036689-116037189 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116037297-116037798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:116045355-116045966 Neighboring gene aurora kinase A pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2843 Neighboring gene von Willebrand factor A domain containing 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:116079781-116080980 Neighboring gene uncharacterized LOC105378494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:116088199-116088844 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:116097011-116098210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116110152-116111044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116164296-116164796 Neighboring gene RNA, 7SL, cytoplasmic 384, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116219699-116220200 Neighboring gene actin binding LIM protein 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:116247470-116248669 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:116249579-116250078 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4083 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:116259001-116260200 Neighboring gene Sharpr-MPRA regulatory region 9264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:116278667-116279186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4088 Neighboring gene Sharpr-MPRA regulatory region 11198 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ14564

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH2 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    actin filament-associated protein 1-like 2
    Names
    AFAP1-like protein 2
    CTB-1144G6.6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001936.3NP_001001936.1  actin filament-associated protein 1-like 2 isoform 1

      See identical proteins and their annotated locations for NP_001001936.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 5' coding region, compared to variant 3. It encodes isoform 1, which is shorter than isoform 3.
      Source sequence(s)
      AB067501, AC005383, AK123108, BC024314, BC033212, BC035713
      Consensus CDS
      CCDS31286.1
      UniProtKB/Swiss-Prot
      A8K6P7, B3KVQ8, Q2UZW3, Q8N4X5, Q8TB54, Q96PX4, Q96SY5
      UniProtKB/TrEMBL
      B7Z2Q0
      Related
      ENSP00000303042.4, ENST00000304129.9
      Conserved Domains (4) summary
      cd13306
      Location:165271
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:353453
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:171270
      PH; PH domain
      pfam06583
      Location:516666
      Neogenin_C; Neogenin C-terminus
    2. NM_001287824.2NP_001274753.1  actin filament-associated protein 1-like 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AB067501, AC005383, AK123108, AK291712, AK294969, BC024314, BC035713
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (4) summary
      cd13306
      Location:218324
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:406506
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:224323
      PH; PH domain
      pfam06583
      Location:569719
      Neogenin_C; Neogenin C-terminus
    3. NM_001351064.2NP_001337993.1  actin filament-associated protein 1-like 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, BC024314, BM918355, DB362446
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (4) summary
      cd13306
      Location:183289
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:371471
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      cl25732
      Location:699765
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26386
      Location:531659
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    4. NM_001351065.2NP_001337994.1  actin filament-associated protein 1-like 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, BC024314, BC033212, BC035713, DA213501
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (3) summary
      cd13306
      Location:193299
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:381481
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      cl25732
      Location:710776
      SMC_N; RecF/RecN/SMC N terminal domain
    5. NM_001351066.2NP_001337995.1  actin filament-associated protein 1-like 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, BC024314, BC033212, BC035713, DA213501
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (3) summary
      cd13306
      Location:193299
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:381481
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      cl25732
      Location:627693
      SMC_N; RecF/RecN/SMC N terminal domain
    6. NM_001351067.2NP_001337996.1  actin filament-associated protein 1-like 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, BC024314, BC033212, BC035713, BM918355, HY263017
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (4) summary
      cd13306
      Location:183289
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:371471
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      cl25732
      Location:699765
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26386
      Location:531659
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    7. NM_001351068.2NP_001337997.1  actin filament-associated protein 1-like 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, BC024314, BC033212, BC035713, BE168197, BM918355
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (3) summary
      cd13306
      Location:183289
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:371471
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      cl25732
      Location:700766
      SMC_N; RecF/RecN/SMC N terminal domain
    8. NM_001351069.2NP_001337998.1  actin filament-associated protein 1-like 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, AL702879, BC024314, BC033212, BC035713, HY263017
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (4) summary
      cd13306
      Location:165271
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:353453
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      cl25732
      Location:681747
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26386
      Location:513641
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    9. NM_001351070.2NP_001337999.1  actin filament-associated protein 1-like 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, BC024314, BC033212, BC035713, BE168197, BM918355, CN298045
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (3) summary
      cd13306
      Location:109215
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:297397
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      cl25732
      Location:626692
      SMC_N; RecF/RecN/SMC N terminal domain
    10. NM_001351071.2NP_001338000.1  actin filament-associated protein 1-like 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, BC024314, BC033212, BC035713, DA122692, DA213501
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (3) summary
      cd13306
      Location:137243
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:325425
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      cl25732
      Location:654720
      SMC_N; RecF/RecN/SMC N terminal domain
    11. NM_001351072.2NP_001338001.1  actin filament-associated protein 1-like 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, BC024314, BC033212, BC035713, DA122692, DA213501, HY263017
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (3) summary
      cd13306
      Location:137243
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:325425
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      cl25732
      Location:653719
      SMC_N; RecF/RecN/SMC N terminal domain
    12. NM_001351073.2NP_001338002.1  actin filament-associated protein 1-like 2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, BC024314, BC033212, BC035713, BE168197, BM918355, CN298045, HY263017
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (3) summary
      cd13306
      Location:109215
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:297397
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      cl25732
      Location:625691
      SMC_N; RecF/RecN/SMC N terminal domain
    13. NM_001351074.2NP_001338003.1  actin filament-associated protein 1-like 2 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, AL702879, BC024314, BC033212, BC035713, HY263017
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (4) summary
      cd13306
      Location:165271
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:353453
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      cl25732
      Location:681747
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26386
      Location:513641
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    14. NM_001351075.2NP_001338004.1  actin filament-associated protein 1-like 2 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, AL702879, BC024314, BC033212, BC035713, BI053053, BM544228, DA164690, DA785568
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (3) summary
      PRK03918
      Location:599665
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd13306
      Location:165271
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:353453
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    15. NM_001351076.2NP_001338005.1  actin filament-associated protein 1-like 2 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, AL702879, BC024314, BC033212, BC035713, BI053053, BM544228, DA164690, DA785568
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (3) summary
      cd13306
      Location:165271
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:353453
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      cl25732
      Location:599665
      SMC_N; RecF/RecN/SMC N terminal domain
    16. NM_001351077.2NP_001338006.1  actin filament-associated protein 1-like 2 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, BC024314, BC033212, BC035713, DA213501, DB362446
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (3) summary
      PRK03918
      Location:709775
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd13306
      Location:193299
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:381481
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
    17. NM_001351078.2NP_001338007.1  actin filament-associated protein 1-like 2 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, BC024314, BC033212, BC035713, DA213501
      Consensus CDS
      CCDS91356.1
      UniProtKB/TrEMBL
      A0A8Q3SIY9, B7Z2Q0
      Related
      ENSP00000512810.1, ENST00000696688.1
      Conserved Domains (3) summary
      cd13306
      Location:193299
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:381481
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      cl25732
      Location:710776
      SMC_N; RecF/RecN/SMC N terminal domain
    18. NM_001351079.2NP_001338008.1  actin filament-associated protein 1-like 2 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, BC024314, BC033212, BC035713, DA213501, DB362446
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (4) summary
      cd13306
      Location:193299
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:381481
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      cl25732
      Location:709775
      SMC_N; RecF/RecN/SMC N terminal domain
      cl26386
      Location:541669
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III
    19. NM_001351080.2NP_001338009.1  actin filament-associated protein 1-like 2 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AB067501, AC005383, AK123108, BC024314, BC033212, BC035713, BM544228, DA213501
      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (3) summary
      cd13306
      Location:193299
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:381481
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      cl25732
      Location:627693
      SMC_N; RecF/RecN/SMC N terminal domain
    20. NM_032550.4NP_115939.1  actin filament-associated protein 1-like 2 isoform 2

      See identical proteins and their annotated locations for NP_115939.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. It encodes isoform 2, which is shorter than isoform 3.
      Source sequence(s)
      AB067501, AC005383, BC024314
      Consensus CDS
      CCDS31287.1
      UniProtKB/TrEMBL
      B7Z2Q0
      Related
      ENSP00000358276.3, ENST00000369271.7
      Conserved Domains (4) summary
      cd13306
      Location:165271
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:353453
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:171270
      PH; PH domain
      pfam06583
      Location:516666
      Neogenin_C; Neogenin C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      114280725..114405175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425858.1XP_047281814.1  actin filament-associated protein 1-like 2 isoform X9

    2. XM_047425857.1XP_047281813.1  actin filament-associated protein 1-like 2 isoform X8

    3. XM_047425856.1XP_047281812.1  actin filament-associated protein 1-like 2 isoform X4

    4. XM_047425854.1XP_047281810.1  actin filament-associated protein 1-like 2 isoform X2

    5. XM_047425855.1XP_047281811.1  actin filament-associated protein 1-like 2 isoform X3

    6. XM_047425853.1XP_047281809.1  actin filament-associated protein 1-like 2 isoform X1

    7. XM_047425873.1XP_047281829.1  actin filament-associated protein 1-like 2 isoform X31

    8. XM_047425865.1XP_047281821.1  actin filament-associated protein 1-like 2 isoform X20

    9. XM_047425864.1XP_047281820.1  actin filament-associated protein 1-like 2 isoform X18

    10. XM_017016804.3XP_016872293.1  actin filament-associated protein 1-like 2 isoform X19

      UniProtKB/TrEMBL
      B7Z2Q0
    11. XM_005270237.6XP_005270294.1  actin filament-associated protein 1-like 2 isoform X17

      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (4) summary
      cd13306
      Location:165271
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:353453
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:171270
      PH; PH domain
      pfam06583
      Location:516666
      Neogenin_C; Neogenin C-terminus
    12. XM_017016818.2XP_016872307.1  actin filament-associated protein 1-like 2 isoform X27

      UniProtKB/TrEMBL
      B7Z2Q0
    13. XM_017016797.2XP_016872286.1  actin filament-associated protein 1-like 2 isoform X7

      UniProtKB/TrEMBL
      B7Z2Q0
    14. XM_017016798.3XP_016872287.1  actin filament-associated protein 1-like 2 isoform X10

      UniProtKB/TrEMBL
      B7Z2Q0
    15. XM_017016796.2XP_016872285.1  actin filament-associated protein 1-like 2 isoform X6

      UniProtKB/TrEMBL
      B7Z2Q0
    16. XM_047425870.1XP_047281826.1  actin filament-associated protein 1-like 2 isoform X26

    17. XM_047425875.1XP_047281831.1  actin filament-associated protein 1-like 2 isoform X33

    18. XM_017016814.2XP_016872303.1  actin filament-associated protein 1-like 2 isoform X26

      UniProtKB/TrEMBL
      B7Z2Q0
    19. XM_005270233.5XP_005270290.1  actin filament-associated protein 1-like 2 isoform X12

      UniProtKB/TrEMBL
      B7Z2Q0
      Conserved Domains (4) summary
      PRK03918
      Location:700766
      PRK03918; DNA double-strand break repair ATPase Rad50
      cd13306
      Location:183289
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:371471
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      NF033201
      Location:498633
      Vip_LPXTG_Lm; cell invasion LPXTG protein Vip
    20. XM_017016795.2XP_016872284.1  actin filament-associated protein 1-like 2 isoform X5

      UniProtKB/TrEMBL
      B7Z2Q0
    21. XM_017016832.2XP_016872321.1  actin filament-associated protein 1-like 2 isoform X28

      UniProtKB/TrEMBL
      B7Z2Q0
    22. XM_047425869.1XP_047281825.1  actin filament-associated protein 1-like 2 isoform X24

    23. XM_047425867.1XP_047281823.1  actin filament-associated protein 1-like 2 isoform X22

    24. XM_047425868.1XP_047281824.1  actin filament-associated protein 1-like 2 isoform X23

    25. XM_047425866.1XP_047281822.1  actin filament-associated protein 1-like 2 isoform X21

    26. XM_047425872.1XP_047281828.1  actin filament-associated protein 1-like 2 isoform X30

    27. XM_047425871.1XP_047281827.1  actin filament-associated protein 1-like 2 isoform X29

    28. XM_047425863.1XP_047281819.1  actin filament-associated protein 1-like 2 isoform X16

    29. XM_047425861.1XP_047281817.1  actin filament-associated protein 1-like 2 isoform X14

    30. XM_047425862.1XP_047281818.1  actin filament-associated protein 1-like 2 isoform X15

    31. XM_047425860.1XP_047281816.1  actin filament-associated protein 1-like 2 isoform X13

    32. XM_047425874.1XP_047281830.1  actin filament-associated protein 1-like 2 isoform X32

    33. XM_017016830.2XP_016872319.1  actin filament-associated protein 1-like 2 isoform X34

    34. XM_017016810.2XP_016872299.1  actin filament-associated protein 1-like 2 isoform X25

      UniProtKB/TrEMBL
      B7Z2Q0
    35. XM_047425859.1XP_047281815.1  actin filament-associated protein 1-like 2 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      115174841..115299200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366963.1XP_054222938.1  actin filament-associated protein 1-like 2 isoform X36

    2. XM_054366976.1XP_054222951.1  actin filament-associated protein 1-like 2 isoform X31

    3. XM_054366969.1XP_054222944.1  actin filament-associated protein 1-like 2 isoform X20

    4. XM_054366967.1XP_054222942.1  actin filament-associated protein 1-like 2 isoform X18

    5. XM_054366968.1XP_054222943.1  actin filament-associated protein 1-like 2 isoform X19

    6. XM_054366966.1XP_054222941.1  actin filament-associated protein 1-like 2 isoform X17

    7. XM_054366974.1XP_054222949.1  actin filament-associated protein 1-like 2 isoform X27

    8. XM_054366962.1XP_054222937.1  actin filament-associated protein 1-like 2 isoform X7

    9. XM_054366964.1XP_054222939.1  actin filament-associated protein 1-like 2 isoform X10

    10. XM_054366961.1XP_054222936.1  actin filament-associated protein 1-like 2 isoform X6

    11. XM_054366973.1XP_054222948.1  actin filament-associated protein 1-like 2 isoform X26

    12. XM_054366978.1XP_054222953.1  actin filament-associated protein 1-like 2 isoform X33

    13. XM_054366972.1XP_054222947.1  actin filament-associated protein 1-like 2 isoform X26

    14. XM_054366965.1XP_054222940.1  actin filament-associated protein 1-like 2 isoform X12

    15. XM_054366960.1XP_054222935.1  actin filament-associated protein 1-like 2 isoform X5

    16. XM_054366959.1XP_054222934.1  actin filament-associated protein 1-like 2 isoform X35

    17. XM_054366975.1XP_054222950.1  actin filament-associated protein 1-like 2 isoform X28

    18. XM_054366970.1XP_054222945.1  actin filament-associated protein 1-like 2 isoform X37

    19. XM_054366977.1XP_054222952.1  actin filament-associated protein 1-like 2 isoform X32

    20. XM_054366979.1XP_054222954.1  actin filament-associated protein 1-like 2 isoform X34

    21. XM_054366971.1XP_054222946.1  actin filament-associated protein 1-like 2 isoform X25