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    SPRY3 sprouty RTK signaling antagonist 3 [ Homo sapiens (human) ]

    Gene ID: 10251, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SPRY3provided by HGNC
    Official Full Name
    sprouty RTK signaling antagonist 3provided by HGNC
    Primary source
    HGNC:HGNC:11271
    See related
    Ensembl:ENSG00000168939 MIM:300531; AllianceGenome:HGNC:11271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    spry-3
    Summary
    Involved in negative regulation of MAPK cascade. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See SPRY3 in Genome Data Viewer
    Location:
    Xq28 and Yq12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (155612586..155782459)
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (56923423..56968979)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (153837809..154007734)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (62159112..62204700)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (154842247..155012121)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (59069571..59115127)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene int22h-3 recombination region Neighboring gene TMLHE antisense RNA 1 Neighboring gene H2A.B variant histone 3 Neighboring gene trimethyllysine hydroxylase, epsilon Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30078 Neighboring gene meiotic recombination hotspot PAR2A Neighboring gene meiotic recombination hotspot PAR2 Neighboring gene adenosylmethionine decarboxylase 1 pseudogene 2 Neighboring gene diphthamide biosynthesis 3 pseudogene 2

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:28797811-28798580 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:28798753-28799442 Neighboring gene poly(ADP-ribose) polymerase family member 4 pseudogene 1 Neighboring gene CCNQ pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrY:58981135-58981878 Neighboring gene meiotic recombination hotspot PAR2 Neighboring gene meiotic recombination hotspot PAR2A Neighboring gene H3K27ac hESC enhancer GRCh37_chrY:58996593-58997092 Neighboring gene OCT4 hESC enhancer GRCh37_chrY:58993067-58993568 Neighboring gene OCT4 hESC enhancer GRCh37_chrY:58991323-58991865 Neighboring gene OCT4 hESC enhancer GRCh37_chrY:58988210-58988711 Neighboring gene OCT4 hESC enhancer GRCh37_chrY:58987057-58987801 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58985458-58986055 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58982623-58983366 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58981879-58982622 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrY:58979645-58980388 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrY:58978901-58979644 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrY:58978157-58978900 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrY:58977411-58978156 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58976667-58977410 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58975923-58976666 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chrY:58975179-58975922 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58971453-58972198 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58861881-58862424 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrY:58862425-58862968 Neighboring gene CTBP2 pseudogene 1 Neighboring gene adenosylmethionine decarboxylase 1 pseudogene 2 Neighboring gene diphthamide biosynthesis 3 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Maintenance of X- and Y-inactivation of the pseudoautosomal (PAR2) gene SPRY3 is independent from DNA methylation and associated to multiple layers of epigenetic modifications. De Bonis ML, et al. Hum Mol Genet, 2006 Apr 1. PMID 16500999
    2. Sprouty3, but Not Sprouty1, Expression Is Beneficial for the Malignant Potential of Osteosarcoma Cells. Kamptner AZM, et al. Int J Mol Sci, 2021 Nov 4. PMID 34769378, Free PMC Article
    3. Sprouty3 and Sprouty4, Two Members of a Family Known to Inhibit FGF-Mediated Signaling, Exert Opposing Roles on Proliferation and Migration of Glioblastoma-Derived Cells. Celik-Selvi BE, et al. Cells, 2019 Aug 1. PMID 31374860, Free PMC Article
    4. The cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes. Lim J, et al. Mol Cell Biol, 2002 Nov. PMID 12391162, Free PMC Article
    5. Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching. Anteby EY, et al. Placenta, 2005 Jul. PMID 15950061

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sprouty3, but Not Sprouty1, Expression Is Beneficial for the Malignant Potential of Osteosarcoma Cells.
      Title: Sprouty3, but Not Sprouty1, Expression Is Beneficial for the Malignant Potential of Osteosarcoma Cells.
    2. The authors presented the data that Spry3 potentiates the tumorigenic potential of glioblastoma cells.
      Title: Sprouty3 and Sprouty4, Two Members of a Family Known to Inhibit FGF-Mediated Signaling, Exert Opposing Roles on Proliferation and Migration of Glioblastoma-Derived Cells.
    3. SPRY3 is a candidate susceptibility locus for autism and related or over-lapping disorders such as ataxia.
      Title: Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region.
    4. the Sprouty/Caveolin-1 interaction modulates signaling in a growth factor- and Sprouty isoform-specific manner
      Title: A functional interaction between sprouty proteins and caveolin-1.
    5. Spry 1, 2 and 3 expression was observed in placental tissue from all three trimesters
      Title: Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of neuron projection arborization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein sprouty homolog 3
    Names
    antagonist of FGF signaling
    sprouty homolog 3
    sprouty3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304990.2 → NP_001291919.1  protein sprouty homolog 3

      See identical proteins and their annotated locations for NP_001291919.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. This variant is only expected to be expressed from the X chromosome. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AJ271735, BX323057, KC877980, KC877984, KC877988, KC877989, KF495814
      Consensus CDS
      CCDS14769.4
      UniProtKB/Swiss-Prot
      A8K0H8, O43610
      Related
      ENSP00000511806.1, ENST00000695325.1
      Conserved Domains (1) summary
      pfam05210
      Location:152 → 253
      Sprouty; Sprouty protein (Spry)

    2. NM_001394353.1 → NP_001381282.1  protein sprouty homolog 3

      Status: VALIDATED

      Source sequence(s)
      AJ271735, BX323057, KC877980, KC877984, KC877988, KC877989, KF495814
      Consensus CDS
      CCDS14769.4
      UniProtKB/Swiss-Prot
      A8K0H8, O43610
      Related
      ENSP00000502489.1, ENST00000675360.1
      Conserved Domains (1) summary
      pfam05210
      Location:152 → 253
      Sprouty; Sprouty protein (Spry)

    3. NM_001394354.1 → NP_001381283.1  protein sprouty homolog 3

      Status: VALIDATED

      Source sequence(s)
      AJ271735, BX323057, KC877980, KC877984, KC877988, KC877989, KF495814
      Consensus CDS
      CCDS14769.4
      UniProtKB/Swiss-Prot
      A8K0H8, O43610
      Conserved Domains (1) summary
      pfam05210
      Location:152 → 253
      Sprouty; Sprouty protein (Spry)

    4. NM_001394355.1 → NP_001381284.1  protein sprouty homolog 3

      Status: VALIDATED

      Source sequence(s)
      AJ271735, BX323057, KC877980, KC877984, KC877988, KC877989, KF495814
      Consensus CDS
      CCDS14769.4
      UniProtKB/Swiss-Prot
      A8K0H8, O43610
      Conserved Domains (1) summary
      pfam05210
      Location:152 → 253
      Sprouty; Sprouty protein (Spry)

    5. NM_005840.4 → NP_005831.1  protein sprouty homolog 3

      See identical proteins and their annotated locations for NP_005831.1

      Status: VALIDATED

      Source sequence(s)
      AJ271735, KC877980, KC877984, KC877988, KC877989, KF495814
      Consensus CDS
      CCDS14769.4
      UniProtKB/Swiss-Prot
      A8K0H8, O43610
      Related
      ENSP00000302978.2, ENST00000302805.7
      Conserved Domains (1) summary
      pfam05210
      Location:152 → 253
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      155612586..155782459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      56923423..56968979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      153837809..154007734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      62159112..62204700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43610.2 GenPept UniProtKB/Swiss-Prot:O43610

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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