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    FCRL1 Fc receptor like 1 [ Homo sapiens (human) ]

    Gene ID: 115350, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FCRL1provided by HGNC
    Official Full Name
    Fc receptor like 1provided by HGNC
    Primary source
    HGNC:HGNC:18509
    See related
    Ensembl:ENSG00000163534 MIM:606508; AllianceGenome:HGNC:18509
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FCRH1; IFGP1; IRTA5; CD307a
    Summary
    This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
    Expression
    Biased expression in lymph node (RPKM 18.4), spleen (RPKM 14.4) and 3 other tissues See more
    Orthologs
    all
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    Genomic context

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    See FCRL1 in Genome Data Viewer
    Location:
    1q23.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (157794403..157820120, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (156931472..156957188, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157764193..157789910, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene voltage dependent anion channel 1 pseudogene 9 Neighboring gene Fc receptor like 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:157739405-157740604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1895 Neighboring gene CD5 molecule like Neighboring gene mitochondrial ribosomal protein S21 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins. Du X, et al. Blood, 2008 Jan 1. PMID 17895404, Free PMC Article
    2. [Expression of human B-cell specific receptor FCRL1 in normal individuals and in patients with autoimmune diseases]. Baranov KO, et al. Mol Biol (Mosk), 2012 May-Jun. PMID 22888639
    3. FCRL1 immunoregulation in B cell development and malignancy. Mamidi MK, et al. Front Immunol, 2023. PMID 37822931, Free PMC Article
    4. FcRH1: an activation coreceptor on human B cells. Leu CM, et al. Blood, 2005 Feb 1. PMID 15479727
    5. A Gene-Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis. Rivera NV, et al. Sci Rep, 2019 Dec 9. PMID 31819081, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FCRL1 immunoregulation in B cell development and malignancy.
      Title: FCRL1 immunoregulation in B cell development and malignancy.
    2. FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2.
      Title: FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2.
    3. Expression profile of Fc receptor-like molecules in patients with IgA nephropathy.
      Title: Expression profile of Fc receptor-like molecules in patients with IgA nephropathy.
    4. A Gene-Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis.
      Title: A Gene-Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis.
    5. FCRL1 gene expression down-regulates in both Hashimoto and Graves disease patients compared to normal subjects.
      Title: Expression Profile of Human Fc Receptor-Like 1, 2, and 4 Molecules in Peripheral Blood Mononuclear Cells of Patients with Hashimoto's Thyroiditis and Graves' Disease.
    6. Data show the Differences in high resolution melting analysis in promoters of tumor markers neuronal membrane glycoprotein M6-B, melanoma antigen family A12 and immunoglobulin superfamily Fc receptor indicated invasiveness of hepatocellular carcinoma.
      Title: Discovery and validation of DNA hypomethylation biomarkers for liver cancer using HRM-specific probes.
    7. Expression level of FCRL1 gene in peripheral blood B-lymphocytes is significantly higher in patients with autoimmune diseases.
      Title: [Expression of human B-cell specific receptor FCRL1 in normal individuals and in patients with autoimmune diseases].
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    10. Down-regulation of FCRL1 is associated with acute lymphoblastic leukemia.
      Title: Low representation of Fc receptor-like 1-5 molecules in leukemic cells from Iranian patients with acute lymphoblastic leukemia.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp667O1421

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables coreceptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fc receptor-like protein 1
    Names
    IFGP family protein 1
    fc receptor homolog 1
    fcR-like protein 1
    hIFGP1
    immune receptor translocation-associated protein 5
    immunoglobulin superfamily Fc receptor, gp42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159397.2 → NP_001152869.1  Fc receptor-like protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001152869.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region compared to variant 1, that results in a frameshift. This variant encodes isoform 2, which is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK096690, AL356276, AL833674, DA939902
      Consensus CDS
      CCDS53382.1
      UniProtKB/Swiss-Prot
      Q96LA6
      Related
      ENSP00000351039.3, ENST00000358292.7
      Conserved Domains (3) summary
      smart00410
      Location:119 → 201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115 → 201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207 → 280
      Ig_3; Immunoglobulin domain

    2. NM_001159398.2 → NP_001152870.1  Fc receptor-like protein 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001152870.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AF329488, AL356276, AL833674, DA939902
      Consensus CDS
      CCDS53383.1
      UniProtKB/Swiss-Prot
      Q96LA6
      Related
      ENSP00000418130.1, ENST00000491942.2
      Conserved Domains (3) summary
      smart00410
      Location:119 → 201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115 → 201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207 → 280
      Ig_3; Immunoglobulin domain

    3. NM_052938.5 → NP_443170.1  Fc receptor-like protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_443170.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL356276, AL833674, AY043464, DA939902
      Consensus CDS
      CCDS1170.1
      UniProtKB/Swiss-Prot
      B2RE05, Q8N759, Q8NDI0, Q96LA6, Q96PJ6
      Related
      ENSP00000357158.3, ENST00000368176.8
      Conserved Domains (3) summary
      smart00410
      Location:119 → 201
      IG_like; Immunoglobulin like
      pfam13895
      Location:19 → 90
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207 → 280
      Ig_3; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      157794403..157820120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005244869.4 → XP_005244926.1  Fc receptor-like protein 1 isoform X11

      Conserved Domains (2) summary
      smart00410
      Location:23 → 105
      IG_like; Immunoglobulin like
      pfam13927
      Location:111 → 184
      Ig_3; Immunoglobulin domain

    2. XM_011509134.3 → XP_011507436.1  Fc receptor-like protein 1 isoform X9

      See identical proteins and their annotated locations for XP_011507436.1

      Conserved Domains (3) summary
      smart00410
      Location:44 → 126
      IG_like; Immunoglobulin like
      pfam13895
      Location:40 → 126
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:132 → 205
      Ig_3; Immunoglobulin domain

    3. XM_011509127.3 → XP_011507429.1  Fc receptor-like protein 1 isoform X3

      Conserved Domains (3) summary
      smart00410
      Location:112 → 194
      IG_like; Immunoglobulin like
      pfam13895
      Location:108 → 194
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:200 → 273
      Ig_3; Immunoglobulin domain

    4. XM_011509135.3 → XP_011507437.1  Fc receptor-like protein 1 isoform X10

      Conserved Domains (2) summary
      smart00410
      Location:30 → 112
      IG_like; Immunoglobulin like
      pfam13927
      Location:118 → 191
      Ig_3; Immunoglobulin domain

    5. XM_011509133.3 → XP_011507435.1  Fc receptor-like protein 1 isoform X9

      See identical proteins and their annotated locations for XP_011507435.1

      Conserved Domains (3) summary
      smart00410
      Location:44 → 126
      IG_like; Immunoglobulin like
      pfam13895
      Location:40 → 126
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:132 → 205
      Ig_3; Immunoglobulin domain

    6. XM_005244867.3 → XP_005244924.1  Fc receptor-like protein 1 isoform X8

      Related
      ENST00000489998.5
      Conserved Domains (3) summary
      smart00410
      Location:119 → 201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115 → 201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207 → 280
      Ig_3; Immunoglobulin domain

    7. XM_011509130.2 → XP_011507432.1  Fc receptor-like protein 1 isoform X7

      Conserved Domains (3) summary
      smart00410
      Location:119 → 201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115 → 201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207 → 280
      Ig_3; Immunoglobulin domain

    8. XM_005244866.3 → XP_005244923.1  Fc receptor-like protein 1 isoform X6

      Conserved Domains (3) summary
      smart00410
      Location:119 → 201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115 → 201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207 → 280
      Ig_3; Immunoglobulin domain

    9. XM_011509129.2 → XP_011507431.1  Fc receptor-like protein 1 isoform X5

      Conserved Domains (3) summary
      smart00410
      Location:119 → 201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115 → 201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207 → 280
      Ig_3; Immunoglobulin domain

    10. XM_011509128.2 → XP_011507430.1  Fc receptor-like protein 1 isoform X4

      Conserved Domains (3) summary
      smart00410
      Location:119 → 201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115 → 201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207 → 280
      Ig_3; Immunoglobulin domain

    11. XM_011509126.2 → XP_011507428.1  Fc receptor-like protein 1 isoform X2

      Conserved Domains (3) summary
      smart00410
      Location:119 → 201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115 → 201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207 → 280
      Ig_3; Immunoglobulin domain

    12. XM_011509125.2 → XP_011507427.1  Fc receptor-like protein 1 isoform X1

      Conserved Domains (3) summary
      smart00410
      Location:119 → 201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115 → 201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207 → 280
      Ig_3; Immunoglobulin domain

    13. XM_047444001.1 → XP_047299957.1  Fc receptor-like protein 1 isoform X13

    14. XM_011509136.2 → XP_011507438.1  Fc receptor-like protein 1 isoform X12

      Conserved Domains (3) summary
      smart00410
      Location:119 → 201
      IG_like; Immunoglobulin like
      pfam13895
      Location:115 → 201
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:207 → 280
      Ig_3; Immunoglobulin domain

    RNA

    1. XR_921738.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      156931472..156957188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334157.1 → XP_054190132.1  Fc receptor-like protein 1 isoform X11

    2. XM_054334155.1 → XP_054190130.1  Fc receptor-like protein 1 isoform X9

    3. XM_054334148.1 → XP_054190123.1  Fc receptor-like protein 1 isoform X3

    4. XM_054334156.1 → XP_054190131.1  Fc receptor-like protein 1 isoform X10

    5. XM_054334154.1 → XP_054190129.1  Fc receptor-like protein 1 isoform X9

    6. XM_054334153.1 → XP_054190128.1  Fc receptor-like protein 1 isoform X8

    7. XM_054334152.1 → XP_054190127.1  Fc receptor-like protein 1 isoform X7

    8. XM_054334151.1 → XP_054190126.1  Fc receptor-like protein 1 isoform X6

    9. XM_054334150.1 → XP_054190125.1  Fc receptor-like protein 1 isoform X5

    10. XM_054334149.1 → XP_054190124.1  Fc receptor-like protein 1 isoform X4

    11. XM_054334147.1 → XP_054190122.1  Fc receptor-like protein 1 isoform X2

    12. XM_054334146.1 → XP_054190121.1  Fc receptor-like protein 1 isoform X1

    13. XM_054334159.1 → XP_054190134.1  Fc receptor-like protein 1 isoform X13

    14. XM_054334158.1 → XP_054190133.1  Fc receptor-like protein 1 isoform X12

    RNA

    1. XR_008485907.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96LA6.1 GenPept UniProtKB/Swiss-Prot:Q96LA6

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