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    CADPS calcium dependent secretion activator [ Homo sapiens (human) ]

    Gene ID: 8618, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CADPSprovided by HGNC
    Official Full Name
    calcium dependent secretion activatorprovided by HGNC
    Primary source
    HGNC:HGNC:1426
    See related
    Ensembl:ENSG00000163618 MIM:604667; AllianceGenome:HGNC:1426
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAPS; CAPS1; CADPS1; UNC-31
    Summary
    This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
    Expression
    Biased expression in brain (RPKM 14.7), adrenal (RPKM 5.4) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CADPS in Genome Data Viewer
    Location:
    3p14.2
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (62398348..62875416, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (62441892..62919090, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (62384023..62861091, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62354716-62355621 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62357949-62358508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62358509-62359066 Neighboring gene VISTA enhancer hs435 Neighboring gene uncharacterized LOC105377647 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62362229-62362828 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62362829-62363426 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:62400506-62401328 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:62401329-62402151 Neighboring gene VISTA enhancer hs1316 Neighboring gene FEZ family zinc finger 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62523426-62524136 Neighboring gene Sharpr-MPRA regulatory region 8400 Neighboring gene Sharpr-MPRA regulatory region 14545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20030 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:62654458-62654958 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:62654959-62655459 Neighboring gene RNA, 7SL, cytoplasmic 863, pseudogene Neighboring gene ribosomal protein L14 pseudogene 2 Neighboring gene RNA, U6 small nuclear 139, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr3:62935781-62936282 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:62936534-62937156 Neighboring gene NANOG hESC enhancer GRCh37_chr3:62940724-62941231 Neighboring gene ribosomal protein S10 pseudogene 10 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:63001433-63002163 Neighboring gene MPRA-validated peak4679 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:63082201-63082700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:63082748-63083248 Neighboring gene keratin 8 pseudogene 35

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A key role for a 145-kDa cytosolic protein in the stimulation of Ca(2+)-dependent secretion by protein kinase C. Nishizaki T, et al. J Biol Chem, 1992 Nov 25. PMID 1429734
    2. Expression of Ca²⁺-dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients. Hattori K, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2011 Aug 15. PMID 21601610
    3. Exosomes isolated from CAPS1‑overexpressing colorectal cancer cells promote cell migration. Wu B, et al. Oncol Rep, 2019 Dec. PMID 31638236, Free PMC Article
    4. CAPS1 Suppresses Tumorigenesis in Cholangiocarcinoma. Weng S, et al. Dig Dis Sci, 2020 Apr. PMID 31562609
    5. A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells. Walent JH, et al. Cell, 1992 Sep 4. PMID 1516133

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress.
      Title: CADPS functional mutations in patients with bipolar disorder increase the sensitivity to stress.
    2. CAPS1 Suppresses Tumorigenesis in Cholangiocarcinoma.
      Title: CAPS1 Suppresses Tumorigenesis in Cholangiocarcinoma.
    3. Study revealed that CAPS1 promoted normal colonic epithelial FHC cells migration by altering the protein expression profile of exosomes derived from colorectal cancer cells cells. GW4869, an exosome inhibitor, inhibited CAPS1-induced cell migration.
      Title: Exosomes isolated from CAPS1‑overexpressing colorectal cancer cells promote cell migration.
    4. CAPS1 promotes colorectal cancer metastasis through PI3K/Akt/GSK3beta/Snail signal pathway-mediated epithelial mesenchymal transformation process
      Title: CAPS1 promotes colorectal cancer metastasis via Snail mediated epithelial mesenchymal transformation.
    5. the preferential binding of CAPS1 to open syntaxin-1 can contribute to the stabilization of the open state of syntaxin-1 during its transition from "closed" state to the SNARE complex formation.
      Title: Calcium-dependent activator protein for secretion 1 (CAPS1) binds to syntaxin-1 in a distinct mode from Munc13-1.
    6. Increased level of CADPS protein, human in Schizophrenic patients
      Title: Expression of Ca²⁺-dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients.
    7. Loss of CADPS is associated with central nervous system primitive neuroectodermal tumor.
      Title: Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma.
    8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic variants associated with breast size also influence breast cancer risk.
    EBI GWAS Catalog
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog
    The genetic architecture of economic and political preferences.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1121

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in dense core granule exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal dense core vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calcium-dependent secretion activator 1
    Names
    CAPS-1
    Ca++-dependent secretion activator
    Ca2+ dependent secretion activator
    Ca2+-dependent activator protein for secretion
    Ca2+-regulated cytoskeletal protein
    calcium-dependent activator protein for secretion 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047093.1 RefSeqGene

      Range
      4974..482042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003716.4 → NP_003707.2  calcium-dependent secretion activator 1 isoform 1

      See identical proteins and their annotated locations for NP_003707.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC012519, AC092039, AC104161
      Consensus CDS
      CCDS46858.1
      UniProtKB/Swiss-Prot
      A6NF60, Q13339, Q6GQQ6, Q8N2Z5, Q8N3M7, Q8NFR0, Q96BC2, Q9ULU8
      Related
      ENSP00000373215.4, ENST00000383710.9
      Conserved Domains (2) summary
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:836 → 940
      DUF1041; Domain of Unknown Function (DUF1041)

    2. NM_183393.3 → NP_899630.1  calcium-dependent secretion activator 1 isoform 3

      See identical proteins and their annotated locations for NP_899630.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is the shortest isoform and lacks multiple internal regions, compared to isoform 1.
      Source sequence(s)
      AC012519, AC092039, AC104161
      Consensus CDS
      CCDS2898.1
      UniProtKB/Swiss-Prot
      Q9ULU8
      Related
      ENSP00000350632.3, ENST00000357948.7
      Conserved Domains (4) summary
      smart00239
      Location:399 → 482
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:523 → 622
      PH; PH domain
      pfam06292
      Location:819 → 910
      DUF1041; Domain of Unknown Function (DUF1041)

    3. NM_183394.3 → NP_899631.1  calcium-dependent secretion activator 1 isoform 2

      See identical proteins and their annotated locations for NP_899631.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than, and contains internal differences, compared to isoform 1.
      Source sequence(s)
      AC012519, AC092039, AC104161
      Consensus CDS
      CCDS2899.1
      UniProtKB/Swiss-Prot
      Q9ULU8
      Related
      ENSP00000283269.9, ENST00000283269.13
      Conserved Domains (2) summary
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:836 → 950
      DUF1041; Domain of Unknown Function (DUF1041)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      62398348..62875416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534200.4 → XP_011532502.1  calcium-dependent secretion activator 1 isoform X45

      See identical proteins and their annotated locations for XP_011532502.1

      Conserved Domains (2) summary
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:836 → 927
      DUF1041; Domain of Unknown Function (DUF1041)

    2. XM_011534199.3 → XP_011532501.1  calcium-dependent secretion activator 1 isoform X43

      Conserved Domains (4) summary
      smart00239
      Location:399 → 482
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:523 → 622
      PH; PH domain
      pfam06292
      Location:836 → 927
      DUF1041; Domain of Unknown Function (DUF1041)

    3. XM_017007378.2 → XP_016862867.1  calcium-dependent secretion activator 1 isoform X35

    4. XM_011534198.4 → XP_011532500.1  calcium-dependent secretion activator 1 isoform X42

      See identical proteins and their annotated locations for XP_011532500.1

      Conserved Domains (2) summary
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:836 → 933
      DUF1041; Domain of Unknown Function (DUF1041)

    5. XM_017007377.3 → XP_016862866.1  calcium-dependent secretion activator 1 isoform X34

    6. XM_011534191.4 → XP_011532493.1  calcium-dependent secretion activator 1 isoform X24

      See identical proteins and their annotated locations for XP_011532493.1

      Conserved Domains (2) summary
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:836 → 950
      DUF1041; Domain of Unknown Function (DUF1041)

    7. XM_017007368.2 → XP_016862857.1  calcium-dependent secretion activator 1 isoform X23

    8. XM_047449109.1 → XP_047305065.1  calcium-dependent secretion activator 1 isoform X47

    9. XM_047449107.1 → XP_047305063.1  calcium-dependent secretion activator 1 isoform X38

    10. XM_047449103.1 → XP_047305059.1  calcium-dependent secretion activator 1 isoform X22

    11. XM_011534197.3 → XP_011532499.1  calcium-dependent secretion activator 1 isoform X36

      See identical proteins and their annotated locations for XP_011532499.1

      UniProtKB/TrEMBL
      F1T0E5
      Related
      ENSP00000484365.1, ENST00000612439.4
      Conserved Domains (4) summary
      smart00239
      Location:399 → 482
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:523 → 622
      PH; PH domain
      pfam06292
      Location:889 → 980
      DUF1041; Domain of Unknown Function (DUF1041)

    12. XM_047449105.1 → XP_047305061.1  calcium-dependent secretion activator 1 isoform X32

    13. XM_006713378.4 → XP_006713441.2  calcium-dependent secretion activator 1 isoform X44

      See identical proteins and their annotated locations for XP_006713441.2

      Conserved Domains (2) summary
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:840 → 931
      DUF1041; Domain of Unknown Function (DUF1041)

    14. XM_047449108.1 → XP_047305064.1  calcium-dependent secretion activator 1 isoform X41

    15. XM_011534203.3 → XP_011532505.1  calcium-dependent secretion activator 1 isoform X48

      See identical proteins and their annotated locations for XP_011532505.1

      Conserved Domains (2) summary
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:840 → 934
      DUF1041; Domain of Unknown Function (DUF1041)

    16. XM_011534196.3 → XP_011532498.1  calcium-dependent secretion activator 1 isoform X30

      Conserved Domains (4) summary
      smart00239
      Location:399 → 482
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:523 → 622
      PH; PH domain
      pfam06292
      Location:840 → 934
      DUF1041; Domain of Unknown Function (DUF1041)

    17. XM_017007386.3 → XP_016862875.1  calcium-dependent secretion activator 1 isoform X40

    18. XM_017007374.3 → XP_016862863.1  calcium-dependent secretion activator 1 isoform X31

      Conserved Domains (2) summary
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:840 → 937
      DUF1041; Domain of Unknown Function (DUF1041)

    19. XM_011534194.3 → XP_011532496.1  calcium-dependent secretion activator 1 isoform X27

      See identical proteins and their annotated locations for XP_011532496.1

      Conserved Domains (2) summary
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:840 → 944
      DUF1041; Domain of Unknown Function (DUF1041)

    20. XM_011534193.3 → XP_011532495.1  calcium-dependent secretion activator 1 isoform X26

      Conserved Domains (1) summary
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

    21. XM_017007383.3 → XP_016862872.1  calcium-dependent secretion activator 1 isoform X39

      Conserved Domains (4) summary
      smart00239
      Location:399 → 482
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:523 → 622
      PH; PH domain
      pfam06292
      Location:840 → 954
      DUF1041; Domain of Unknown Function (DUF1041)

    22. XM_047449106.1 → XP_047305062.1  calcium-dependent secretion activator 1 isoform X37

    23. XM_047449102.1 → XP_047305058.1  calcium-dependent secretion activator 1 isoform X20

    24. XM_017007376.3 → XP_016862865.1  calcium-dependent secretion activator 1 isoform X33

    25. XM_011534195.3 → XP_011532497.1  calcium-dependent secretion activator 1 isoform X29

      Conserved Domains (4) summary
      smart00239
      Location:399 → 482
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:523 → 622
      PH; PH domain
      pfam06292
      Location:893 → 984
      DUF1041; Domain of Unknown Function (DUF1041)

    26. XM_011534183.3 → XP_011532485.1  calcium-dependent secretion activator 1 isoform X14

      Conserved Domains (4) summary
      smart00239
      Location:399 → 482
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:523 → 622
      PH; PH domain
      pfam06292
      Location:893 → 984
      DUF1041; Domain of Unknown Function (DUF1041)

    27. XM_047449099.1 → XP_047305055.1  calcium-dependent secretion activator 1 isoform X11

    28. XM_017007371.3 → XP_016862860.1  calcium-dependent secretion activator 1 isoform X28

    29. XM_017007363.3 → XP_016862852.1  calcium-dependent secretion activator 1 isoform X13

    30. XM_011534182.3 → XP_011532484.1  calcium-dependent secretion activator 1 isoform X12

      Conserved Domains (4) summary
      smart00239
      Location:399 → 482
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:523 → 622
      PH; PH domain
      pfam06292
      Location:893 → 990
      DUF1041; Domain of Unknown Function (DUF1041)

    31. XM_011534180.3 → XP_011532482.1  calcium-dependent secretion activator 1 isoform X10

      Conserved Domains (4) summary
      smart00239
      Location:399 → 482
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:523 → 622
      PH; PH domain
      pfam06292
      Location:893 → 997
      DUF1041; Domain of Unknown Function (DUF1041)

    32. XM_011534192.3 → XP_011532494.1  calcium-dependent secretion activator 1 isoform X25

      Conserved Domains (4) summary
      smart00239
      Location:399 → 482
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:523 → 622
      PH; PH domain
      pfam06292
      Location:893 → 993
      DUF1041; Domain of Unknown Function (DUF1041)

    33. XM_047449098.1 → XP_047305054.1  calcium-dependent secretion activator 1 isoform X9

    34. XM_017007366.3 → XP_016862855.1  calcium-dependent secretion activator 1 isoform X21

      Conserved Domains (1) summary
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain

    35. XM_011534189.3 → XP_011532491.1  calcium-dependent secretion activator 1 isoform X18

      Conserved Domains (4) summary
      smart00239
      Location:399 → 482
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:523 → 622
      PH; PH domain
      pfam06292
      Location:893 → 1007
      DUF1041; Domain of Unknown Function (DUF1041)

    36. XM_047449097.1 → XP_047305053.1  calcium-dependent secretion activator 1 isoform X8

    37. XM_011534178.3 → XP_011532480.1  calcium-dependent secretion activator 1 isoform X7

      Conserved Domains (4) summary
      smart00239
      Location:399 → 482
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:523 → 622
      PH; PH domain
      pfam06292
      Location:893 → 1007
      DUF1041; Domain of Unknown Function (DUF1041)

    38. XM_047449094.1 → XP_047305050.1  calcium-dependent secretion activator 1 isoform X2

    39. XM_047449101.1 → XP_047305057.1  calcium-dependent secretion activator 1 isoform X19

    40. XM_047449100.1 → XP_047305056.1  calcium-dependent secretion activator 1 isoform X16

    41. XM_047449096.1 → XP_047305052.1  calcium-dependent secretion activator 1 isoform X5

    42. XM_047449095.1 → XP_047305051.1  calcium-dependent secretion activator 1 isoform X4

    43. XM_047449093.1 → XP_047305049.1  calcium-dependent secretion activator 1 isoform X1

    44. XM_017007364.3 → XP_016862853.1  calcium-dependent secretion activator 1 isoform X17

    45. XM_024453799.2 → XP_024309567.1  calcium-dependent secretion activator 1 isoform X15

      Conserved Domains (2) summary
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam06292
      Location:893 → 1013
      DUF1041; Domain of Unknown Function (DUF1041)

    46. XM_017007360.3 → XP_016862849.1  calcium-dependent secretion activator 1 isoform X6

    47. XM_011534177.3 → XP_011532479.1  calcium-dependent secretion activator 1 isoform X3

      Conserved Domains (4) summary
      smart00239
      Location:399 → 482
      C2; Protein kinase C conserved region 2 (CalB)
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:523 → 622
      PH; PH domain
      pfam06292
      Location:893 → 1013
      DUF1041; Domain of Unknown Function (DUF1041)

    48. XM_011534202.4 → XP_011532504.1  calcium-dependent secretion activator 1 isoform X46

      Conserved Domains (3) summary
      cd01234
      Location:515 → 634
      PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
      pfam00169
      Location:523 → 622
      PH; PH domain
      pfam06292
      Location:893 → 918
      DUF1041; Domain of Unknown Function (DUF1041)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      62441892..62919090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348213.1 → XP_054204188.1  calcium-dependent secretion activator 1 isoform X45

    2. XM_054348211.1 → XP_054204186.1  calcium-dependent secretion activator 1 isoform X43

    3. XM_054348203.1 → XP_054204178.1  calcium-dependent secretion activator 1 isoform X35

    4. XM_054348210.1 → XP_054204185.1  calcium-dependent secretion activator 1 isoform X42

    5. XM_054348202.1 → XP_054204177.1  calcium-dependent secretion activator 1 isoform X34

    6. XM_054348192.1 → XP_054204167.1  calcium-dependent secretion activator 1 isoform X24

    7. XM_054348191.1 → XP_054204166.1  calcium-dependent secretion activator 1 isoform X23

    8. XM_054348214.1 → XP_054204189.1  calcium-dependent secretion activator 1 isoform X47

    9. XM_054348206.1 → XP_054204181.1  calcium-dependent secretion activator 1 isoform X38

    10. XM_054348190.1 → XP_054204165.1  calcium-dependent secretion activator 1 isoform X22

    11. XM_054348204.1 → XP_054204179.1  calcium-dependent secretion activator 1 isoform X36

      UniProtKB/TrEMBL
      F1T0E5

    12. XM_054348200.1 → XP_054204175.1  calcium-dependent secretion activator 1 isoform X32

    13. XM_054348170.1 → XP_054204145.1  calcium-dependent secretion activator 1 isoform X49

    14. XM_054348212.1 → XP_054204187.1  calcium-dependent secretion activator 1 isoform X44

    15. XM_054348209.1 → XP_054204184.1  calcium-dependent secretion activator 1 isoform X41

    16. XM_054348215.1 → XP_054204190.1  calcium-dependent secretion activator 1 isoform X48

    17. XM_054348198.1 → XP_054204173.1  calcium-dependent secretion activator 1 isoform X30

    18. XM_054348208.1 → XP_054204183.1  calcium-dependent secretion activator 1 isoform X40

    19. XM_054348199.1 → XP_054204174.1  calcium-dependent secretion activator 1 isoform X31

    20. XM_054348195.1 → XP_054204170.1  calcium-dependent secretion activator 1 isoform X27

    21. XM_054348194.1 → XP_054204169.1  calcium-dependent secretion activator 1 isoform X26

    22. XM_054348207.1 → XP_054204182.1  calcium-dependent secretion activator 1 isoform X39

    23. XM_054348205.1 → XP_054204180.1  calcium-dependent secretion activator 1 isoform X37

    24. XM_054348188.1 → XP_054204163.1  calcium-dependent secretion activator 1 isoform X20

    25. XM_054348201.1 → XP_054204176.1  calcium-dependent secretion activator 1 isoform X33

    26. XM_054348197.1 → XP_054204172.1  calcium-dependent secretion activator 1 isoform X29

    27. XM_054348182.1 → XP_054204157.1  calcium-dependent secretion activator 1 isoform X14

    28. XM_054348179.1 → XP_054204154.1  calcium-dependent secretion activator 1 isoform X11

    29. XM_054348196.1 → XP_054204171.1  calcium-dependent secretion activator 1 isoform X28

    30. XM_054348181.1 → XP_054204156.1  calcium-dependent secretion activator 1 isoform X13

    31. XM_054348180.1 → XP_054204155.1  calcium-dependent secretion activator 1 isoform X12

    32. XM_054348178.1 → XP_054204153.1  calcium-dependent secretion activator 1 isoform X10

    33. XM_054348193.1 → XP_054204168.1  calcium-dependent secretion activator 1 isoform X25

    34. XM_054348177.1 → XP_054204152.1  calcium-dependent secretion activator 1 isoform X9

    35. XM_054348189.1 → XP_054204164.1  calcium-dependent secretion activator 1 isoform X21

    36. XM_054348186.1 → XP_054204161.1  calcium-dependent secretion activator 1 isoform X18

    37. XM_054348176.1 → XP_054204151.1  calcium-dependent secretion activator 1 isoform X8

    38. XM_054348175.1 → XP_054204150.1  calcium-dependent secretion activator 1 isoform X7

    39. XM_054348169.1 → XP_054204144.1  calcium-dependent secretion activator 1 isoform X2

    40. XM_054348187.1 → XP_054204162.1  calcium-dependent secretion activator 1 isoform X19

    41. XM_054348184.1 → XP_054204159.1  calcium-dependent secretion activator 1 isoform X16

    42. XM_054348173.1 → XP_054204148.1  calcium-dependent secretion activator 1 isoform X5

    43. XM_054348172.1 → XP_054204147.1  calcium-dependent secretion activator 1 isoform X4

    44. XM_054348168.1 → XP_054204143.1  calcium-dependent secretion activator 1 isoform X1

    45. XM_054348185.1 → XP_054204160.1  calcium-dependent secretion activator 1 isoform X17

    46. XM_054348183.1 → XP_054204158.1  calcium-dependent secretion activator 1 isoform X15

    47. XM_054348174.1 → XP_054204149.1  calcium-dependent secretion activator 1 isoform X6

    48. XM_054348171.1 → XP_054204146.1  calcium-dependent secretion activator 1 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULU8.3 GenPept UniProtKB/Swiss-Prot:Q9ULU8

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