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    TAGAP T cell activation RhoGTPase activating protein [ Homo sapiens (human) ]

    Gene ID: 117289, updated on 9-Dec-2024

    Summary

    Official Symbol
    TAGAPprovided by HGNC
    Official Full Name
    T cell activation RhoGTPase activating proteinprovided by HGNC
    Primary source
    HGNC:HGNC:15669
    See related
    Ensembl:ENSG00000164691 MIM:609667; AllianceGenome:HGNC:15669
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FKSG15; IDDM21; TAGAP1; ARHGAP47
    Summary
    This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
    Expression
    Biased expression in bone marrow (RPKM 44.8), lymph node (RPKM 19.7) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TAGAP in Genome Data Viewer
    Location:
    6q25.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (159034481..159044991, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (160280073..160290583, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (159455513..159466023, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr6:159357268-159357370 Neighboring gene RNA, U6 small nuclear 293, pseudogene Neighboring gene radial spoke head 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159419977-159420948 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:159420949-159421920 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25380 Neighboring gene TAGAP antisense RNA 1 Neighboring gene MPRA-validated peak6278 silencer Neighboring gene MPRA-validated peak6279 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25381 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25382 Neighboring gene MPRA-validated peak6280 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:159461684-159462883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25383 Neighboring gene uncharacterized LOC112267968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25385 Neighboring gene uncharacterized LOC124901449 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17748 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25386 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:159538123-159538330 Neighboring gene VISTA enhancer hs2576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17750 Neighboring gene FNDC1 antisense RNA 1 Neighboring gene fibronectin type III domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.
    EBI GWAS Catalog
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    EBI GWAS Catalog
    Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
    EBI GWAS Catalog
    Genome-wide interaction study of smoking and bladder cancer risk.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    EBI GWAS Catalog
    Newly identified genetic risk variants for celiac disease related to the immune response.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of T-cell activation RhoGTPase activating protein (TAGAP) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ32631, FLJ39771, MGC27381, MGC133247

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
     
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    T-cell activation Rho GTPase-activating protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011524.1 RefSeqGene

      Range
      5162..15672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001278733.2NP_001265662.1  T-cell activation Rho GTPase-activating protein isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate 5'-most exon, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (d) has a shorter N-terminus, compared to isoform b.
      Source sequence(s)
      AF385429, AL035530, DA819174
      UniProtKB/TrEMBL
      B4DQ86
      Conserved Domains (1) summary
      cd04402
      Location:22218
      RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...
    2. NM_054114.5NP_473455.2  T-cell activation Rho GTPase-activating protein isoform b

      See identical proteins and their annotated locations for NP_473455.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (b).
      Source sequence(s)
      AF385429, AL035530
      Consensus CDS
      CCDS5261.1
      UniProtKB/Swiss-Prot
      Q2NKM8, Q8N103, Q8NI40, Q96KZ2, Q96QA2
      UniProtKB/TrEMBL
      B4DQ86
      Related
      ENSP00000356033.4, ENST00000367066.8
      Conserved Domains (1) summary
      cd04402
      Location:85281
      RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...
    3. NM_138810.4NP_620165.1  T-cell activation Rho GTPase-activating protein isoform c

      See identical proteins and their annotated locations for NP_620165.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 2. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform b.
      Source sequence(s)
      AF385429, AL035530, BC015859
      Consensus CDS
      CCDS5263.1
      UniProtKB/Swiss-Prot
      Q8N103
      Related
      ENSP00000340217.5, ENST00000338313.5
      Conserved Domains (1) summary
      cd04402
      Location:85264
      RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...
    4. NM_152133.3NP_687034.1  T-cell activation Rho GTPase-activating protein isoform a

      See identical proteins and their annotated locations for NP_687034.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an exon in the coding region compared to variant 2, resulting in the use of a downstream start codon. The encoded isoform (a) has a shorter N-terminus compared to isoform b.
      Source sequence(s)
      AF385430, AL035530
      Consensus CDS
      CCDS5262.1
      UniProtKB/TrEMBL
      B4DQ86
      Related
      ENSP00000322650.6, ENST00000326965.7
      Conserved Domains (1) summary
      cl02570
      Location:1103
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      159034481..159044991 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      160280073..160290583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)