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    TSR3 TSR3 ribosome maturation factor [ Homo sapiens (human) ]

    Gene ID: 115939, updated on 9-Dec-2024

    Summary

    Official Symbol
    TSR3provided by HGNC
    Official Full Name
    TSR3 ribosome maturation factorprovided by HGNC
    Primary source
    HGNC:HGNC:14175
    See related
    Ensembl:ENSG00000007520 MIM:617058; AllianceGenome:HGNC:14175
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HsTsr3; C16orf42
    Summary
    Enables 18S rRNA aminocarboxypropyltransferase activity. Involved in enzyme-directed rRNA pseudouridine synthesis. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in fat (RPKM 23.3), kidney (RPKM 22.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TSR3 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1349240..1351878, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1365417..1368055, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1399241..1401879, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:1360147-1360758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10219 Neighboring gene ubiquitin conjugating enzyme E2 I Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10221 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1382600-1382800 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6970 Neighboring gene ribosomal protein S20 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1388370-1389219 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1392110-1392658 Neighboring gene BAI1 associated protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6972 Neighboring gene N-acetylglucosamine-1-phosphate transferase subunit gamma Neighboring gene unk like zinc finger Neighboring gene tight junction protein 1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC24381

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 18S rRNA aminocarboxypropyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables S-adenosyl-L-methionine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in enzyme-directed rRNA pseudouridine synthesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in rRNA modification TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    18S rRNA aminocarboxypropyltransferase
    Names
    20S S rRNA accumulation protein 3 homolog
    TSR3, 20S rRNA accumulation, homolog
    TSR3, acp transferase ribosome maturation factor
    probable ribosome biogenesis protein C16orf42
    ribosome biogenesis protein TSR3 homolog
    NP_001001410.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001410.3NP_001001410.1  18S rRNA aminocarboxypropyltransferase

      See identical proteins and their annotated locations for NP_001001410.1

      Status: VALIDATED

      Source sequence(s)
      AL031709, BC016699, BC017325
      Consensus CDS
      CCDS10435.1
      UniProtKB/Swiss-Prot
      Q6PJT8, Q9UJK0
      Related
      ENSP00000007390.2, ENST00000007390.3
      Conserved Domains (3) summary
      PRK02287
      Location:65223
      PRK02287; hypothetical protein; Provisional
      pfam04034
      Location:96220
      DUF367; Domain of unknown function (DUF367)
      pfam04068
      Location:6092
      RLI; Possible Fer4-like domain in RNase L inhibitor, RLI

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      1349240..1351878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      1365417..1368055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)