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    DNAJC22 DnaJ heat shock protein family (Hsp40) member C22 [ Homo sapiens (human) ]

    Gene ID: 79962, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DNAJC22provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C22provided by HGNC
    Primary source
    HGNC:HGNC:25802
    See related
    Ensembl:ENSG00000178401 AllianceGenome:HGNC:25802
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    wus
    Summary
    Predicted to be active in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver (RPKM 7.7), duodenum (RPKM 7.3) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DNAJC22 in Genome Data Viewer
    Location:
    12q13.12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (49346888..49353690)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (49309047..49315879)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49740671..49747473)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene TROAP and PRPH antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6313 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:49724253-49724754 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49729567-49730366 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:49736353-49736864 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4430 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4431 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4432 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4433 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:49741370-49742313 Neighboring gene trophinin associated protein Neighboring gene complement C1q like 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4435 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4437 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6315 Neighboring gene spermatogenesis associated serine rich 2 Neighboring gene FGFR1 oncogene partner 2 pseudogene Neighboring gene Sharpr-MPRA regulatory region 14813 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:49846952-49847452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49873095-49873682 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:49907610-49907788 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4438 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49932121-49932932 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:49932933-49933742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6316 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:49936243-49937442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:49941330-49942138 Neighboring gene uncharacterized LOC105369761 Neighboring gene potassium voltage-gated channel subfamily H member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Wurst is essential for airway clearance and respiratory-tube size control. Behr M, et al. Nat Cell Biol, 2007 Jul. PMID 17558392
    2. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. Yeung ML, et al. J Biol Chem, 2009 Jul 17. PMID 19460752, Free PMC Article
    3. Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains. Piette BL, et al. Mol Cell, 2021 Jun 17. PMID 33957083
    4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of DnaJ (Hsp40) homolog, subfamily C, member 22 (DNAJC22) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13236

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 22
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 22
    wurst homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304944.2 → NP_001291873.1  dnaJ homolog subfamily C member 22

      See identical proteins and their annotated locations for NP_001291873.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC125611, AK055747
      Consensus CDS
      CCDS8785.1
      UniProtKB/Swiss-Prot
      B3KP54, Q8N4W6
      Related
      ENSP00000446830.1, ENST00000549441.7
      Conserved Domains (1) summary
      smart00271
      Location:278 → 335
      DnaJ; DnaJ molecular chaperone homology domain

    2. NM_024902.4 → NP_079178.2  dnaJ homolog subfamily C member 22

      See identical proteins and their annotated locations for NP_079178.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC125611, AK055747, BC033236
      Consensus CDS
      CCDS8785.1
      UniProtKB/Swiss-Prot
      B3KP54, Q8N4W6
      Related
      ENSP00000378508.2, ENST00000395069.3
      Conserved Domains (1) summary
      smart00271
      Location:278 → 335
      DnaJ; DnaJ molecular chaperone homology domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      49346888..49353690
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429555.1 → XP_047285511.1  dnaJ homolog subfamily C member 22 isoform X1

    2. XM_047429556.1 → XP_047285512.1  dnaJ homolog subfamily C member 22 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      49309047..49315879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373252.1 → XP_054229227.1  dnaJ homolog subfamily C member 22 isoform X1

    2. XM_054373253.1 → XP_054229228.1  dnaJ homolog subfamily C member 22 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N4W6.1 GenPept UniProtKB/Swiss-Prot:Q8N4W6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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