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    oxyR transcriptional regulator [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878254, updated on 24-Aug-2024

    Summary

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    Gene symbol
    oxyR
    Gene description
    transcriptional regulator
    Locus tag
    PA5344
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (6012047..6012979)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene transcriptional regulator Neighboring gene hypothetical protein Neighboring gene ATP-dependent DNA helicase RecG Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DsbM affects aminoglycoside resistance in Pseudomonas aeruginosa by the reduction of OxyR. Li M, et al. FEMS Microbiol Lett, 2014 Mar. PMID 24456559
    2. A proteome analysis of the response of a Pseudomonas aeruginosa oxyR mutant to iron limitation. Vinckx T, et al. Biometals, 2011 Jun. PMID 21207115
    3. The major catalase gene (katA) of Pseudomonas aeruginosa PA14 is under both positive and negative control of the global transactivator OxyR in response to hydrogen peroxide. Heo YJ, et al. J Bacteriol, 2010 Jan. PMID 19933365, Free PMC Article
    4. Global regulation of gene expression by OxyR in an important human opportunistic pathogen. Wei Q, et al. Nucleic Acids Res, 2012 May. PMID 22275523, Free PMC Article
    5. The Pseudomonas aeruginosa oxidative stress regulator OxyR influences production of pyocyanin and rhamnolipids: protective role of pyocyanin. Vinckx T, et al. Microbiology (Reading), 2010 Mar. PMID 19926657

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hypothesized that OxyR can be reduced by DsbM, and thus DsbM may be required for aminoglycoside resistance in P. aeruginosa.
      Title: DsbM affects aminoglycoside resistance in Pseudomonas aeruginosa by the reduction of OxyR.
    2. Collectively, the results indicate that OxyR is involved in oxidative stress defense and regulates other aspects of cellular metabolism as well.
      Title: Global regulation of gene expression by OxyR in an important human opportunistic pathogen.
    3. Results describe the effects caused by iron limitation on the physiological proteomic response of the oxyR mutant in Pseudomonas aeruginosa.
      Title: A proteome analysis of the response of a Pseudomonas aeruginosa oxyR mutant to iron limitation.
    4. Mutation in OxyR causes an increase of pyocyanin production, strongly decreased swarming motility, and absence of rhamnolipid production.
      Title: The Pseudomonas aeruginosa oxidative stress regulator OxyR influences production of pyocyanin and rhamnolipids: protective role of pyocyanin.
    5. Inactivation of the oxyR gene in Pseudomonas aeruginosa PAO1 impairs pyoverdine-mediated iron uptake and growth under iron limited conditions.
      Title: Loss of the oxidative stress regulator OxyR in Pseudomonas aeruginosa PAO1 impairs growth under iron-limited conditions.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of secondary metabolite biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of lipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of superoxide dismutase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcriptional regulator
    NP_254031.1
    • Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      6012047..6012979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_254031.1 transcriptional regulator [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_254031.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q9HTL4
      Conserved Domains (2) summary
      cd08411
      Location:92 → 293
      PBP2_OxyR; The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00126
      Location:3 → 62
      HTH_1; Bacterial regulatory helix-turn-helix protein, lysR family
    Nucleotide Protein
    Heading Accession and Version

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