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    mexD resistance-nodulation-cell division (RND) multidrug efflux transporter MexD [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 881071, updated on 24-Aug-2024

    Summary

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    Gene symbol
    mexD
    Gene description
    resistance-nodulation-cell division (RND) multidrug efflux transporter MexD
    Locus tag
    PA4598
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5151078..5154209, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene transcriptional regulator Neighboring gene multidrug efflux outer membrane protein OprJ Neighboring gene resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexC Neighboring gene transcriptional regulator NfxB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction of mexCD-oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1. Morita Y, et al. J Antimicrob Chemother, 2003 Apr. PMID 12654738
    2. Sub-inhibitory concentrations of antibiotics and wastewater influencing biofilm formation and gene expression of multi-resistant Pseudomonas aeruginosa wastewater isolates. Bruchmann J, et al. Environ Sci Pollut Res Int, 2013 Jun. PMID 23392972
    3. Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa. Linares JF, et al. J Bacteriol, 2005 Feb. PMID 15687203, Free PMC Article
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Subinhibitory concentrations of macrolides specifically upregulated expression of quorum sensing genes (rhlR, lasI), whereas sulfonamides and municipal wastewater, instead upregulated expression of specific resistant genes (sul1) and efflux pumps (mexD).
      Title: Sub-inhibitory concentrations of antibiotics and wastewater influencing biofilm formation and gene expression of multi-resistant Pseudomonas aeruginosa wastewater isolates.
    2. results presented here indicate that the transcriptional activation of the T3S regulon is reduced in mutants overexpressing either the MexCD-OprJ or MexEF-OprN MDR pump, making these mutants less cytotoxic
      Title: Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa.
    3. The MexCD-OprJ operon is induced by some disinfectants and cytotoxic agents. Cells showed increased resistance to norfloxacin when grown in the presence of the inducers of the operon.
      Title: Induction of mexCD-oprJ operon for a multidrug efflux pump by disinfectants in wild-type Pseudomonas aeruginosa PAO1.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    resistance-nodulation-cell division (RND) multidrug efflux transporter MexD
    NP_253288.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5151078..5154209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253288.1 resistance-nodulation-cell division (RND) multidrug efflux transporter MexD [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253288.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q51396
      Conserved Domains (1) summary
      TIGR00915
      Location:1 → 1038
      2A0602; The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family
    Nucleotide Protein
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