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    wrbA NAD(P)H dehydrogenase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882021, updated on 24-Aug-2024

    Summary

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    Gene symbol
    wrbA
    Gene description
    NAD(P)H dehydrogenase
    Locus tag
    PA0949
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (1036579..1037175, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene DNA replication initiation factor Neighboring gene hypothetical protein Neighboring gene arsenate reductase Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pseudomonas aeruginosa MdaB and WrbA are water-soluble two-electron quinone oxidoreductases with the potential to defend against oxidative stress. Green LK, et al. J Microbiol, 2014 Sep. PMID 25085734
    2. WrbA from Escherichia coli and Archaeoglobus fulgidus is an NAD(P)H:quinone oxidoreductase. Patridge EV, et al. J Bacteriol, 2006 May. PMID 16672604, Free PMC Article
    3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
    5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Despite not conferring a growth advantage to wild type Pseudomonas aeruginosa, it is possible that the MdaB and WrbA quinone oxidoreductases defend against H2O2 toxicity at lower concentrations.
      Title: Pseudomonas aeruginosa MdaB and WrbA are water-soluble two-electron quinone oxidoreductases with the potential to defend against oxidative stress.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables NAD(P)H dehydrogenase (quinone) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAD(P)H dehydrogenase
    NP_249640.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      1036579..1037175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249640.1 NAD(P)H dehydrogenase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249640.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A367MA67
      Conserved Domains (1) summary
      cl00438
      Location:6 → 196
      FMN_red; NADPH-dependent FMN reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I509.1

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