mrp-7 Multidrug resistance protein mrp-7 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mrp-7
Official Full Name: Multidrug resistance protein mrp-7
Primary source: WormBase:WBGene00003413
Locus tag: CELE_Y43F8C.12
See related: AllianceGenome:WB:WBGene00003413
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in response to methylmercury. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in body wall musculature; intestine; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including bile duct disease (multiple); bilirubin metabolic disorder (multiple); leukemia (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human ABCC1 (ATP binding cassette subfamily C member 1 (ABCC1 blood group)) and ABCC2 (ATP binding cassette subfamily C member 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mrp-7 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 14

Sequence:: Chromosome: V; NC_003283.11 (19674843..19693049)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here, we report that a gene coding for the putative multidrug resistance protein MRP-7 in Caenorhabditis elegans modulates whole animal and dopamine neuron sensitivity to methylmercury.
Title: The putative multidrug resistance protein MRP-7 inhibits methylmercury-associated animal toxicity and dopaminergic neurodegeneration in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y116F11A.zz5 (e-PCR)
- UniSTS:323862

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in response to methylmercury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to methylmercury	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Multidrug resistance protein mrp-7

NP_507812.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

19674843..19693049

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075411.6 → NP_507812.3 Multidrug resistance protein mrp-7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_507812.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U2G5

Conserved Domains (1) summary

TIGR00957
Location:14 → 1518

MRP_assoc_pro; multi drug resistance-associated protein (MRP)