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    snf-3 Sodium- and chloride-dependent betaine transporter [ Caenorhabditis elegans ]

    Gene ID: 173493, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snf-3
    Official Full Name
    Sodium- and chloride-dependent betaine transporter
    Primary source
    WormBase:WBGene00004902
    Locus tag
    CELE_T13B5.1
    See related
    AllianceGenome:WB:WBGene00004902
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables amino-acid betaine transmembrane transporter activity. Involved in amino-acid betaine transport. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. Is expressed in excretory cell; hypodermis; nervous system; and vulval cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snf-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (1092006..1097899)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene C6 domain-containing protein Neighboring gene tRNA Neighboring gene Histidine acid phosphatase Neighboring gene Leishmanolysin-like peptidase Neighboring gene tRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Betaine acts on a ligand-gated ion channel in the nervous system of the nematode C. elegans. Peden AS, et al. Nat Neurosci, 2013 Dec. PMID 24212673, Free PMC Article
    2. The Caenorhabditis elegans snf-11 gene encodes a sodium-dependent GABA transporter required for clearance of synaptic GABA. Mullen GP, et al. Mol Biol Cell, 2006 Jul. PMID 16641366, Free PMC Article
    3. Neuronally produced betaine acts via a ligand-gated ion channel to control behavioral states. Hardege I, et al. Proc Natl Acad Sci U S A, 2022 Nov 29. PMID 36413500, Free PMC Article
    4. The signaling pathway of levamisole-sensitive-acetylcholine receptors involved in short-term forgetting of Caenorhabditis elegans. Niu S, et al. Mol Genet Genomics, 2022 Jul. PMID 35585325
    5. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables amino-acid betaine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables gamma-aminobutyric acid:sodium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino-acid betaine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sodium- and chloride-dependent betaine transporter
    NP_493910.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      1092006..1097899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061509.10 → NP_493910.2  Sodium- and chloride-dependent betaine transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493910.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBN9
      Conserved Domains (1) summary
      cd11496
      Location:30 → 571
      SLC6sbd-TauT-like; Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EBN9.1

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