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    F25B5.6 Putative folylpolyglutamate synthase [ Caenorhabditis elegans ]

    Gene ID: 175842, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F25B5.6
    Official Full Name
    Putative folylpolyglutamate synthase
    Primary source
    WormBase:WBGene00017777
    Locus tag
    CELE_F25B5.6
    See related
    AllianceGenome:WB:WBGene00017777
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable tetrahydrofolylpolyglutamate synthase activity. Predicted to be involved in tetrahydrofolylpolyglutamate biosynthetic process. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be active in cytosol and mitochondrion. Is expressed in hypodermis; intestine; nervous system; and pharynx. Orthologous to human FPGS (folylpolyglutamate synthase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F25B5.6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (5946215..5948733, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Ubiquitin-related Neighboring gene CDK5RAP1-like protein Neighboring gene 5'-nucleotidase;Putative cytosolic 5'-nucleotidase 3;Transposase Neighboring gene NOPS domain-containing protein;RRM domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    2. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
    3. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    4. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tetrahydrofolylpolyglutamate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tetrahydrofolylpolyglutamate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in folic acid-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolylpolyglutamate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tetrahydrofolylpolyglutamate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Putative folylpolyglutamate synthase
    NP_001022548.1
    • Confirmed by transcript evidence
    NP_001359969.1
    • Confirmed by transcript evidence
    NP_498291.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5946215..5948733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065890.2 → NP_498291.1  Putative folylpolyglutamate synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498291.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09509
      Conserved Domains (2) summary
      TIGR01499
      Location:79 → 516
      folC; folylpolyglutamate synthase/dihydrofolate synthase
      pfam02875
      Location:350 → 407
      Mur_ligase_C; Mur ligase family, glutamate ligase domain

    2. NM_001372603.2 → NP_001359969.1  Putative folylpolyglutamate synthase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09509, Q5DX42, Q95QJ2
      Conserved Domains (1) summary
      TIGR01499
      Location:68 → 505
      folC; folylpolyglutamate synthase/dihydrofolate synthase

    3. NM_001027377.6 → NP_001022548.1  Putative folylpolyglutamate synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022548.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09509
      Conserved Domains (2) summary
      TIGR01499
      Location:42 → 479
      folC; folylpolyglutamate synthase/dihydrofolate synthase
      pfam02875
      Location:313 → 370
      Mur_ligase_C; Mur ligase family, glutamate ligase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09509.1

    Gene LinkOut

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