U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ifc-2 IF rod domain-containing protein;Intermediate Filament, C;Intermediate filament protein ifc-2 [ Caenorhabditis elegans ]

    Gene ID: 180414, updated on 9-Dec-2024

    Summary

    Official Symbol
    ifc-2
    Official Full Name
    IF rod domain-containing protein;Intermediate Filament, C;Intermediate filament protein ifc-2
    Primary source
    WormBase:WBGene00002056
    Locus tag
    CELE_M6.1
    See related
    AllianceGenome:WB:WBGene00002056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of cytoskeleton. Involved in post-embryonic digestive tract morphogenesis. Located in cytoplasm and desmosome. Is expressed in several structures, including excretory cell; intestine; pharynx; rectal valve cell; and uterus. Human ortholog(s) of this gene implicated in several diseases, including Dowling-Degos disease; Meesmann corneal dystrophy 2; epidermolysis bullosa simplex (multiple); ichthyosis (multiple); and palmoplantar keratosis (multiple). Orthologous to several human genes including KRT1 (keratin 1); KRT10 (keratin 10); and KRT2 (keratin 2). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ifc-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    24
    Sequence:
    Chromosome: X; NC_003284.9 (642156..654904, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Galectin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene LiPocalin-Related protein Neighboring gene RUN domain-containing protein Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene ncRNA

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear envelope organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear pore localization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in post-embryonic digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in desmosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nuclear lamina IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    IF rod domain-containing protein;Intermediate Filament, C;Intermediate filament protein ifc-2
    NP_001256975.1
    • Confirmed by transcript evidence
    NP_001362085.1
    • Confirmed by transcript evidence
    NP_001367765.1
    • Confirmed by transcript evidence
    NP_001379332.1
    • Product from WormBase gene class ifc;
      Partially confirmed by transcript evidence
    NP_001379874.1
    • Confirmed by transcript evidence
    NP_001380259.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      642156..654904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380893.1NP_001367765.1  Intermediate filament protein ifc-2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam00038
      Location:6901033
      Filament; Intermediate filament protein
    2. NM_001270046.2NP_001256975.1  Intermediate filament protein ifc-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256975.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02366, Q21067, Q21579, Q21580
      UniProtKB/TrEMBL
      G8JY94
      Conserved Domains (2) summary
      pfam00038
      Location:51394
      Filament; Intermediate filament protein
      cl01090
      Location:318387
      SlyX; SlyX
    3. NM_001374936.2NP_001362085.1  Intermediate filament protein ifc-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5E4LYE2
      Conserved Domains (1) summary
      pfam00038
      Location:7681111
      Filament; Intermediate filament protein
    4. NM_001392718.1NP_001379874.1  Intermediate filament protein ifc-2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      pfam00038
      Location:6901033
      Filament; Intermediate filament protein
    5. NM_001392719.1NP_001380259.1  IF rod domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5E4M3F7
      Conserved Domains (1) summary
      pfam00038
      Location:51394
      Filament; Intermediate filament protein
    6. NM_001392720.1NP_001379332.1  Intermediate Filament, C [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7I9BEY5