rig-6 Contactin rig-6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rig-6
Official Full Name: Contactin rig-6
Primary source: WormBase:WBGene00016354
Locus tag: CELE_C33F10.5
See related: AllianceGenome:WB:WBGene00016354
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cell-cell adhesion mediator activity. Involved in several processes, including axon guidance; negative regulation of defecation rhythm; and negative regulation of locomotion involved in locomotory behavior. Located in axon; neuronal cell body; and synapse. Is expressed in several structures, including body wall musculature; neurons; non-striated muscle; rectal epithelium; and spermatheca. Human ortholog(s) of this gene implicated in Compton-North congenital myopathy and familial adult myoclonic epilepsy 5. Orthologous to several human genes including CNTN6 (contactin 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rig-6 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 14

Sequence:: Chromosome: II; NC_003280.10 (4798151..4812086, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The contactin RIG-6 mediates neuronal and non-neuronal cell migration in Caenorhabditis elegans.
Title: The contactin RIG-6 mediates neuronal and non-neuronal cell migration in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C33F10.6 (e-PCR)
- UniSTS:313802

C33F10.5 (e-PCR)
- UniSTS:308697

STS2-242 (e-PCR)
- UniSTS:241918

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of left/right asymmetry in nervous system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal/ventral axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of defecation rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axon extension involved in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of distal tip cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Contactin rig-6

NP_001022014.1

Confirmed by transcript evidence

NP_001364725.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

4798151..4812086 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001026843.8 → NP_001022014.1 Contactin rig-6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022014.1

Status: REVIEWED

UniProtKB/Swiss-Prot

H2KZ60, Q18382, Q8MQA8, Q9BIA2

Conserved Domains (6) summary

smart00408
Location:456 → 524

IGc2; Immunoglobulin C-2 Type

smart00410
Location:363 → 436

IG_like; Immunoglobulin like

cd00063
Location:737 → 839

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:441 → 534

I-set; Immunoglobulin I-set domain

pfam00041
Location:970 → 1047

fn3; Fibronectin type III domain

cl11960
Location:358 → 427

Ig; Immunoglobulin domain
NM_001377791.2 → NP_001364725.1 Contactin rig-6 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (4) summary

smart00409
Location:133 → 205

IG; Immunoglobulin

cd00063
Location:315 → 417

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:18 → 99

Ig_3; Immunoglobulin domain

cd00096
Location:27 → 30

Ig; Ig strand A' [structural motif]