dhgd-1 D-2-hydroxyglutarate dehydrogenase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: dhgd-1
Official Full Name: D-2-hydroxyglutarate dehydrogenase, mitochondrial
Primary source: WormBase:WBGene00010055
Locus tag: CELE_F54D5.12
See related: AllianceGenome:WB:WBGene00010055
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable catalytic activity and flavin adenine dinucleotide binding activity. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 1. Orthologous to human D2HGDH (D-2-hydroxyglutarate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See dhgd-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (11538904..11540630, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F54D5.12 (e-PCR)
- UniSTS:320822

F54D5.11 (e-PCR)
- UniSTS:314445

Y62F5A.e (e-PCR)
- UniSTS:323202

F54D5.8 (e-PCR)
- UniSTS:311775

F54D5.9 (e-PCR)
- UniSTS:311776

F54D5.7 (e-PCR)
- UniSTS:307698

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: D-2-hydroxyglutarate dehydrogenase, mitochondrial

NP_496465.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

11538904..11540630 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064064.9 → NP_496465.1 D-2-hydroxyglutarate dehydrogenase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_496465.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EE46

Conserved Domains (1) summary

COG0277
Location:37 → 485

GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]