sig-7 Peptidyl-prolyl cis-trans isomerase sig-7 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sig-7
Official Full Name: Peptidyl-prolyl cis-trans isomerase sig-7
Primary source: WormBase:WBGene00000890
Locus tag: CELE_F39H2.2
See related: AllianceGenome:WB:WBGene00000890
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA polymerase II complex binding activity. Involved in several processes, including positive regulation of gastrulation; positive regulation of oocyte development; and positive regulation of vulval development. Located in euchromatin and nucleoplasm. Is expressed in several structures, including intestine. Orthologous to human PPIL4 (peptidylprolyl isomerase like 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sig-7 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (8646451..8651671)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our findings suggest that SIG-7 plays a central role in both Pol II elongation and co-transcriptional splicing and may provide an important link for their coordination and regulation
Title: A Conserved Nuclear Cyclophilin Is Required for Both RNA Polymerase II Elongation and Co-transcriptional Splicing in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS1-21 (e-PCR)
- UniSTS:241702

VF39H2L.1 (e-PCR)
- UniSTS:318566

F39H2.2 (e-PCR)
- UniSTS:314270

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II complex binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein peptidyl-prolyl isomerization	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation-coupled chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Peptidyl-prolyl cis-trans isomerase sig-7

NP_001359651.1

Confirmed by transcript evidence

NP_492343.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

8646451..8651671

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059942.9 → NP_492343.2 Peptidyl-prolyl cis-trans isomerase sig-7 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492343.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EEW6, Q8I4J2

Conserved Domains (3) summary

COG0724
Location:128 → 346

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd01921
Location:4 → 169

cyclophilin_RRM; cyclophilin_RRM: cyclophilin-type peptidylprolyl cis- trans isomerase domain occuring with a C-terminal RNA recognition motif domain (RRM). This subfamily of the cyclophilin domain family contains a number of eukaryotic cyclophilins having the RRM domain ...

cd12235
Location:238 → 320

RRM_PPIL4; RNA recognition motif in peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) and similar proteins
NM_001373191.3 → NP_001359651.1 Peptidyl-prolyl cis-trans isomerase sig-7 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

cd12235
Location:169 → 251

RRM_PPIL4; RNA recognition motif in peptidyl-prolyl cis-trans isomerase-like 4 (PPIase) and similar proteins

cl00197
Location:1 → 100

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...