gana-1 Alpha-galactosidase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gana-1
Official Full Name: Alpha-galactosidase
Primary source: WormBase:WBGene00011095
Locus tag: CELE_R07B7.11
See related: AllianceGenome:WB:WBGene00011095
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable alpha-galactosidase activity. Involved in glycoside catabolic process. Located in cytoplasm. Is expressed in several structures, including arcade cell; body wall musculature; coelomocyte; intestine; and pharynx. Used to study Fabry disease. Human ortholog(s) of this gene implicated in Fabry disease; Kanzaki disease; Schindler disease type 1; angiokeratoma; and neuroaxonal dystrophy. Orthologous to human NAGA (alpha-N-acetylgalactosaminidase) and GLA (galactosidase alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gana-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (12087234..12088931)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of dual active sites in Caenorhabditis elegans GANA-1 protein: an ortholog of the human alpha-GAL a and alpha-NAGA enzymes.
Title: Identification of dual active sites in Caenorhabditis elegans GANA-1 protein: an ortholog of the human α-GAL a and α-NAGA enzymes.
GANA-1 is a single C. elegans ortholog of both human alpha-GAL and alpha-NAGA proteins. Evidence presented supports the hypothesis that GANA-1 has dual enzymatic activity and is localized in an acidic cellular compartment.
Title: Characterization of gana-1, a Caenorhabditis elegans gene encoding a single ortholog of vertebrate alpha-galactosidase and alpha-N-acetylgalactosaminidase.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R07B7.11 (e-PCR)
- UniSTS:321623

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables alpha-galactosidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-galactosidase activity	IEA Inferred from Electronic Annotation more info
enables galactosidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycoside catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycoside catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligosaccharide metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Alpha-galactosidase

NP_506031.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

12087234..12088931

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073630.9 → NP_506031.1 Alpha-galactosidase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506031.1

Status: REVIEWED

UniProtKB/TrEMBL

Q21801

Conserved Domains (1) summary

cl07893
Location:23 → 397

AmyAc_family; Alpha amylase catalytic domain family