pptr-1 Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pptr-1
Official Full Name: Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1
Primary source: WormBase:WBGene00012348
Locus tag: CELE_W08G11.4
See related: AllianceGenome:WB:WBGene00012348
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein kinase binding activity and protein phosphatase activator activity. Contributes to protein serine/threonine phosphatase activity. Involved in several processes, including P granule assembly; determination of adult lifespan; and negative regulation of insulin receptor signaling pathway. Located in cytosol. Is expressed in several structures, including excretory cell; intestine; nervous system; pharynx; and reproductive system. Used to study cancer. Orthologous to several human genes including PPP2R5E (protein phosphatase 2 regulatory subunit B'epsilon). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pptr-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 10

Sequence:: Chromosome: V; NC_003283.11 (16357521..16367574)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Modulation of pptr-1 affects insulin/IGF-1 signaling pathway-associated phenotypes including life span, dauer, stress resistance, and fat storage; study shows that PPTR-1 functions by regulating worm AKT-1 phosphorylation at Thr 350.
Title: A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W08G11.4 (e-PCR)
- UniSTS:320378

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein phosphatase regulator activity	IEA Inferred from Electronic Annotation more info
contributes_to protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in P granule assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in P granule assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of lipid storage	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to heat	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IC Inferred by Curator more info	PubMed
part_of protein phosphatase type 2A complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1

NP_507133.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

16357521..16367574

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074732.6 → NP_507133.4 Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_507133.4

Status: REVIEWED

UniProtKB/Swiss-Prot

O18178

Conserved Domains (2) summary

PLN00122
Location:384 → 478

PLN00122; serine/threonine protein phosphatase 2A; Provisional

pfam01603
Location:81 → 478

B56; Protein phosphatase 2A regulatory B subunit (B56 family)