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    tars-1 Threonine--tRNA ligase, cytoplasmic;threonine--tRNA ligase [ Caenorhabditis elegans ]

    Gene ID: 174790, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tars-1
    Official Full Name
    Threonine--tRNA ligase, cytoplasmic;threonine--tRNA ligase
    Primary source
    WormBase:WBGene00006617
    Locus tag
    CELE_C47D12.6
    See related
    AllianceGenome:WB:WBGene00006617
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable threonine-tRNA ligase activity. Involved in determination of adult lifespan. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in anal depressor muscle; body wall musculature; intestine; and pharynx. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21 and nonphotosensitive trichothiodystrophy 7. Orthologous to several human genes including TARS3 (threonyl-tRNA synthetase 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See tars-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (11691325..11694293, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene CUB domain-containing protein Neighboring gene BTB domain-containing protein Neighboring gene ERCC4 domain-containing protein Neighboring gene inositol-3-phosphate synthase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial translational defect extends lifespan in C. elegans by activating UPR(mt). Guo M, et al. Redox Biol, 2023 Jul. PMID 37167879, Free PMC Article
    2. Use of cDNA subtraction and RNA interference screens in combination reveals genes required for germ-line development in Caenorhabditis elegans. Hanazawa M, et al. Proc Natl Acad Sci U S A, 2001 Jul 17. PMID 11447255, Free PMC Article
    3. Coordinate Regulation of Ribosome and tRNA Biogenesis Controls Hypoxic Injury and Translation. Itani OA, et al. Curr Biol, 2021 Jan 11. PMID 33157031, Free PMC Article
    4. Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Maeda I, et al. Curr Biol, 2001 Feb 6. PMID 11231151
    5. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Chen D, et al. Aging Cell, 2007 Aug. PMID 17521386, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables threonine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables threonine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in threonyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Threonine--tRNA ligase, cytoplasmic;threonine--tRNA ligase
    NP_001022033.1
    • Confirmed by transcript evidence
    NP_001379393.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11691325..11694293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026862.7 → NP_001022033.1  Threonine--tRNA ligase, cytoplasmic [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022033.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52709
      Conserved Domains (5) summary
      cd01667
      Location:82 → 143
      TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
      PLN02908
      Location:46 → 714
      PLN02908; threonyl-tRNA synthetase
      smart00863
      Location:249 → 296
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cd00771
      Location:320 → 617
      ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00860
      Location:617 → 708
      ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

    2. NM_001393202.1 → NP_001379393.1  threonine--tRNA ligase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86D21
      Conserved Domains (1) summary
      PLN02908
      Location:5 → 673
      PLN02908; threonyl-tRNA synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52709.1

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