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    cup-4 Acetylcholine receptor-like protein cup-4 [ Caenorhabditis elegans ]

    Gene ID: 176104, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cup-4
    Official Full Name
    Acetylcholine receptor-like protein cup-4
    Primary source
    WormBase:WBGene00000845
    Locus tag
    CELE_C02C2.3
    See related
    AllianceGenome:WB:WBGene00000845
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable neurotransmitter receptor activity. Involved in several processes, including determination of adult lifespan; positive regulation of egg-laying behavior; and response to caloric restriction. Located in cytoplasmic vesicle membrane. Is expressed in coelomocyte. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cup-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (7866489..7868737)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative transporter slc-17.3 Neighboring gene putative small nuclear ribonucleoprotein F Neighboring gene Putative tyrosinase-like protein tyr-1 Neighboring gene Iodotyrosine dehalogenase 1 homolog Neighboring gene TIP41-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lifespan regulation under axenic dietary restriction: a close look at the usual suspects. Castelein N, et al. Exp Gerontol, 2014 Oct. PMID 25066271
    2. Calcineurin regulates coelomocyte endocytosis via DYN-1 and CUP-4 in Caenorhabditis elegans. Song HO, et al. Mol Cells, 2010 Sep. PMID 20803083
    3. Dirofilaria immitis: identification of a novel ligand-gated ion channel-related polypeptide. Yates DM, et al. Exp Parasitol, 2004 Nov-Dec. PMID 15582516
    4. Endocytic coelomocytes are required for lifespan extension by axenic dietary restriction. Mergan L, et al. PLoS One, 2023. PMID 37368903, Free PMC Article
    5. Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. Park SK, et al. Aging Cell, 2009 Jun. PMID 19627265, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cup-4, a gene required for efficient endocytosis by C. elegans coelomocytes, is specifically required for dietary restricction-induced longevity
      Title: Life-span extension by dietary restriction is mediated by NLP-7 signaling and coelomocyte endocytosis in C. elegans.
    2. CUP-4 regulates endocytosis through modulation of phospholipase C activity.
      Title: Endocytosis function of a ligand-gated ion channel homolog in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acetylcholine receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables excitatory extracellular ligand-gated monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to caloric restriction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to caloric restriction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to paraquat IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to paraquat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, cholinergic IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transmembrane transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Acetylcholine receptor-like protein cup-4
    NP_498710.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7866489..7868737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066309.6 → NP_498710.2  Acetylcholine receptor-like protein cup-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498710.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34271, Q6IZD3
      Conserved Domains (1) summary
      pfam02931
      Location:48 → 222
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34271.2

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