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    gpx-6 Glutathione peroxidase [ Caenorhabditis elegans ]

    Gene ID: 188313, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gpx-6
    Official Full Name
    Glutathione peroxidase
    Primary source
    WormBase:WBGene00020373
    Locus tag
    CELE_T09A12.2
    See related
    AllianceGenome:WB:WBGene00020373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peroxidase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Predicted to be located in extracellular space. Is expressed in body wall musculature and nervous system. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gpx-6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_003282.8 (8222202..8223461)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Serine protease svh-1 Neighboring gene ELM2 domain-containing protein Neighboring gene Ion transport domain-containing protein Neighboring gene Stress-associated endoplasmic reticulum protein Neighboring gene Nuclear hormone receptor family member nhr-66 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Acute, reproductive, and developmental toxicity of essential oils assessed with alternative in vitro and in vivo systems. Lanzerstorfer P, et al. Arch Toxicol, 2021 Feb. PMID 33159585, Free PMC Article
    2. Antioxidant enzymes and their role in phoxim and carbaryl stress in Caenorhabditis elegans. Han Y, et al. Pestic Biochem Physiol, 2017 May. PMID 28456303
    3. Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans. Liu Z, et al. J Hazard Mater, 2024 Jun 5. PMID 38643579
    4. Toxicity of nonylphenol and nonylphenol ethoxylate on Caenorhabditis elegans. De la Parra-Guerra A, et al. Ecotoxicol Environ Saf, 2020 Jan 15. PMID 31654870
    5. Deletion of the four phospholipid hydroperoxide glutathione peroxidase genes accelerates aging in Caenorhabditis elegans. Sakamoto T, et al. Genes Cells, 2014 Oct. PMID 25200408

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Glutathione peroxidase
    NP_001023368.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8222202..8223461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028197.6 → NP_001023368.1  Glutathione peroxidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023368.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYJ6
      Conserved Domains (1) summary
      cd00340
      Location:30 → 182
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

    RNA

    1. NR_131582.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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