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    • Showing Current items.

    tsp-15 Tetraspanin-15 [ Caenorhabditis elegans ]

    Gene ID: 192065, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tsp-15
    Official Full Name
    Tetraspanin-15
    Primary source
    WormBase:WBGene00006641
    Locus tag
    CELE_F53B6.1
    See related
    AllianceGenome:WB:WBGene00006641
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and skin epidermis development. Predicted to be located in membrane. Is expressed in body wall musculature; hyp7 syncytium; pharynx; seam cell; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tsp-15 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (8928750..8931089)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene SH2 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Protein madd-4 Neighboring gene Fungus-Induced Protein Neighboring gene FIP (Fungus-Induced Protein) Related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recruitment of tetraspanin TSP-15 to epidermal wounds promotes plasma membrane repair in C. elegans. Wang Y, et al. Dev Cell, 2022 Jul 11. PMID 35777354
    2. Isolation of intragenic suppressor of tsp-15-splicing mutant in Caenorhabditis elegans. Moribe H, et al. MicroPubl Biol, 2019 Jul 23. PMID 32550409, Free PMC Article
    3. Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes. Moribe H, et al. Worm, 2013 Apr 1. PMID 24058871, Free PMC Article
    4. The BLI-3/TSP-15/DOXA-1 dual oxidase complex is required for iodide toxicity in Caenorhabditis elegans. Xu Z, et al. G3 (Bethesda), 2014 Dec 4. PMID 25480962, Free PMC Article
    5. Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans. Moribe H, et al. PLoS Genet, 2012 Sep. PMID 23028364, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BLI-3/TSP-15/DOXA-1 dual oxidase complex is required for the toxic pleiotropic effects of excess iodide.
      Title: The BLI-3/TSP-15/DOXA-1 dual oxidase complex is required for iodide toxicity in Caenorhabditis elegans.
    2. We demonstrated that TSP-15, BLI-3, and DOXA-1 form complexes in vitro and in vivo. Cell-fusion-based analysis suggested that association with TSP-15 at the cell surface is crucial for BLI-3 activation to release H(2)O(2).
      Title: Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans.
    3. TSP-15 functions in the maintenance of epithelial cell integrity
      Title: Tetraspanin protein (TSP-15) is required for epidermal integrity in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skin epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tetraspanin-15
    NP_492404.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8928750..8931089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060003.7 → NP_492404.1  Tetraspanin-15 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492404.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XVM9
      Conserved Domains (2) summary
      cd03156
      Location:110 → 228
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:16 → 256
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XVM9.2

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