cox-5B COX5B-domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cox-5B
Official Full Name: COX5B-domain-containing protein
Primary source: WormBase:WBGene00000371
Locus tag: CELE_F26E4.9
See related: AllianceGenome:WB:WBGene00000371
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable metal ion binding activity. Involved in determination of adult lifespan; lipid storage; and proton motive force-driven mitochondrial ATP synthesis. Predicted to be located in mitochondrial envelope. Predicted to be part of respiratory chain complex IV. Orthologous to human COX5B (cytochrome c oxidase subunit 5B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cox-5B in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (9789009..9789851)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The GCN-2 pathway was not required for the longevity phenotype of cco-1 worms.
Title: The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F26E4.9 (e-PCR)
- UniSTS:316637

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, cytochrome c to oxygen	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven mitochondrial ATP synthesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial envelope	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex IV	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: COX5B-domain-containing protein

NP_492601.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

9789009..9789851

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060200.7 → NP_492601.1 COX5B-domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492601.1

Status: REVIEWED

UniProtKB/TrEMBL

P90849

Conserved Domains (1) summary

cd00924
Location:36 → 130

Cyt_c_Oxidase_Vb; Cytochrome c oxidase subunit Vb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...