vbh-1 RNA helicase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: vbh-1
Official Full Name: RNA helicase
Primary source: WormBase:WBGene00006888
Locus tag: CELE_Y54E10A.9
See related: AllianceGenome:WB:WBGene00006888
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA helicase activity and mRNA binding activity. Involved in several processes, including masculinization of hermaphroditic germ-line; positive regulation of embryonic development; and positive regulation of fertilization. Located in P granule and cytoplasmic stress granule. Is expressed in several structures, including Z2; Z3; germ cell; germ line; and somatic cell. Human ortholog(s) of this gene implicated in colorectal cancer and syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See vbh-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (3158492..3162391, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VBH-1 plays an important role during the stress response in C. elegans through the potential direct or indirect regulation of stress response mRNAs.
Title: The DEAD Box RNA helicase VBH-1 is a new player in the stress response in C. elegans.
VBH-1 might play a role in germ cell survival in both species albeit it appears to have an opposite role in each one.
Title: Germ cell survival in C. elegans and C. remanei is affected when the DEAD box RNA helicases VBH-1 or Cre-VBH-1 are silenced.
VBH-1 and its orthologs may perform conserved roles in fertility and development.
Title: The DEAD box RNA helicase VBH-1 is required for germ cell function in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y54E10A_159.b (e-PCR)
- UniSTS:323101

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamete generation	IBA Inferred from Biological aspect of Ancestor more info
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in masculinization of hermaphroditic germ-line	IGI Inferred from Genetic Interaction more info	PubMed
involved_in masculinization of hermaphroditic germ-line	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of fertilization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of fertilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in P granule	IBA Inferred from Biological aspect of Ancestor more info
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in P granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: RNA helicase

NP_001021793.1

Confirmed by transcript evidence

NP_001370791.1

Confirmed by transcript evidence

NP_491113.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3158492..3162391 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058712.5 → NP_491113.1 RNA helicase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491113.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9N3F4

Conserved Domains (3) summary

PTZ00424
Location:118 → 509

PTZ00424; helicase 45; Provisional

cd00079
Location:352 → 482

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:122 → 342

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
NM_001383938.2 → NP_001370791.1 RNA helicase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q95XY1

Conserved Domains (1) summary

COG0513
Location:124 → 514

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
NM_001026622.2 → NP_001021793.1 RNA helicase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021793.1

Status: REVIEWED

UniProtKB/TrEMBL

Q65XX1

Conserved Domains (3) summary

PTZ00424
Location:137 → 528

PTZ00424; helicase 45; Provisional

cd00079
Location:371 → 501

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:141 → 361

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...