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    F43C11.7 RING-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173591, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F43C11.7
    Official Full Name
    RING-type domain-containing protein
    Primary source
    WormBase:WBGene00018384
    Locus tag
    CELE_F43C11.7
    See related
    AllianceGenome:WB:WBGene00018384
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable zinc ion binding activity. Involved in defense response to Gram-positive bacterium and determination of adult lifespan. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; Sweet syndrome; asthma; familial Mediterranean fever; and hematologic cancer (multiple). Orthologous to several human genes including BSPRY (B-box and SPRY domain containing); MEFV (MEFV innate immunity regulator, pyrin); and RNF39 (ring finger protein 39). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F43C11.7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (2335897..2337696)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene RING-type domain-containing protein Neighboring gene RING-type domain-containing protein Neighboring gene Enhanced Nuclear RnaI (RNAi), T. Duchaine Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct pathogenesis and host responses during infection of C. elegans by P. aeruginosa and S. aureus. Irazoqui JE, et al. PLoS Pathog, 2010 Jul 1. PMID 20617181, Free PMC Article
    2. Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes. Visvikis O, et al. Immunity, 2014 Jun 19. PMID 24882217, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RING-type domain-containing protein
    NP_494245.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      2335897..2337696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061844.7 → NP_494245.1  RING-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494245.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U5C1
      Conserved Domains (3) summary
      cd00162
      Location:6 → 50
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl00034
      Location:91 → 140
      Bbox_SF; B-box-type zinc finger superfamily
      cl17238
      Location:5 → 51
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
    Heading Accession and Version

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