ceh-100 Homeobox domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ceh-100
Official Full Name: Homeobox domain-containing protein
Primary source: WormBase:WBGene00012584
Locus tag: CELE_Y38E10A.6
See related: AllianceGenome:WB:WBGene00012584
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in brain development; neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed widely. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ceh-100 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 18

Sequence:: Chromosome: II; NC_003280.10 (12582178..12603680, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y38E10A.f (e-PCR)
- UniSTS:322759

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Homeobox domain-containing protein

NP_001022428.1

Confirmed by transcript evidence

NP_001022429.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

12582178..12603680 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001027258.5 → NP_001022429.1 Homeobox domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022429.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7K714

Conserved Domains (2) summary

smart00389
Location:1075 → 1127

HOX; Homeodomain

cd00086
Location:112 → 159

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_001027257.6 → NP_001022428.1 Homeobox domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001022428.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9U2M6

Conserved Domains (2) summary

smart00389
Location:1073 → 1125

HOX; Homeodomain

cd00086
Location:110 → 157

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.