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    oxy-4 putative cytosolic Fe-S cluster assembly factor oxy-4 [ Caenorhabditis elegans ]

    Gene ID: 175702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    oxy-4
    Official Full Name
    putative cytosolic Fe-S cluster assembly factor oxy-4
    Primary source
    WormBase:WBGene00021902
    Locus tag
    CELE_Y54H5A.4
    See related
    AllianceGenome:WB:WBGene00021902
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity and metal ion binding activity. Predicted to be involved in iron-sulfur cluster assembly. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Orthologous to several human genes including CIAO3 (cytosolic iron-sulfur assembly component 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See oxy-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (5155462..5158774, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene RNA-binding protein 42 Neighboring gene Glutamate-rich WD repeat-containing protein 1 Neighboring gene pseudo Neighboring gene Trafficking protein particle complex subunit 2-like protein Neighboring gene Glycine--tRNA ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [FeFe]-hydrogenase-like gene is involved in the regulation of sensitivity to oxygen in yeast and nematode. Fujii M, et al. Genes Cells, 2009 Apr. PMID 19335616
    2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggested that [FeFe]-hydrogenase-like genes (Y54H5A.4) was involved in the regulation of sensitivity to oxygen.
      Title: [FeFe]-hydrogenase-like gene is involved in the regulation of sensitivity to oxygen in yeast and nematode.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic [4Fe-4S] assembly targeting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative cytosolic Fe-S cluster assembly factor oxy-4
    NP_498092.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5155462..5158774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065691.8 → NP_498092.4  putative cytosolic Fe-S cluster assembly factor oxy-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498092.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N392
      Conserved Domains (2) summary
      COG4624
      Location:50 → 445
      Nar1; Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]
      pfam02906
      Location:102 → 391
      Fe_hyd_lg_C; Iron only hydrogenase large subunit, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N392.5

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