abi-1 SH3 domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: abi-1
Official Full Name: SH3 domain-containing protein
Primary source: WormBase:WBGene00015146
Locus tag: CELE_B0336.6
See related: AllianceGenome:WB:WBGene00015146
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables SH3 domain binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of endocytosis; presynaptic actin cytoskeleton organization; and synaptic vesicle clustering. Located in several cellular components, including axon; dendrite; and neuronal cell body. Is expressed in coelomocyte; head neurons; and ventral cord neurons. Orthologous to several human genes including ABI1 (abl interactor 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See abi-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 5

Sequence:: Chromosome: III; NC_003281.10 (5690107..5692730, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these observations suggest that MIG-10 interacts with ABI-1 and WVE-1 to mediate the UNC-6 and SLT-1 guidance pathways.
Title: MIG-10 functions with ABI-1 to mediate the UNC-6 and SLT-1 axon guidance signaling pathways.
Abelson interactor-1 (ABI-1) interacts with MRL adaptor protein MIG-10 and is required in guided cell migrations and process outgrowth in C. elegans.
Title: Abelson interactor-1 (ABI-1) interacts with MRL adaptor protein MIG-10 and is required in guided cell migrations and process outgrowth in C. elegans.
MIG-10B interacts with Abl-interacting protein-1 (ABI-1)/Abi1, a component of the WAVE complex, to organize the actin cytoskeleton at presynaptic sites and instruct vesicle clustering through SNN-1/Synapsin
Title: Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin.
UNC-53/NAV2, through its calponin homology domain, acts as a scaffold that links ABI-1 to the ARP2/3 complex to regulate actin cytoskeleton remodeling.
Title: The cell migration molecule UNC-53/NAV2 is linked to the ARP2/3 complex by ABI-1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0336.5 (e-PCR)
- UniSTS:313393

B0336.6 (e-PCR)
- UniSTS:313394

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell projection morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of engulfment of apoptotic cell	IGI Inferred from Genetic Interaction more info	PubMed
involved_in presynaptic actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle clustering	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCAR complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in actin-based cell projection	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SH3 domain-containing protein

NP_498224.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5690107..5692730 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065823.7 → NP_498224.1 SH3 domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498224.1

Status: REVIEWED

UniProtKB/TrEMBL

Q10929

Conserved Domains (2) summary

cd11826
Location:416 → 466

SH3_Abi; Src homology 3 domain of Abl Interactor proteins

pfam07815
Location:95 → 169

Abi_HHR; Abl-interactor HHR